Results 81 to 90 of about 273,241 (304)

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

Using linkage maps to correct and scaffold de novo genome assemblies: Methods, challenges and computational tools

open access: yesFrontiers in Genetics, 2015
Modern high-throughput DNA sequencing has made it possible to inexpensively produce genome sequences, but in practice many of these draft genomes are fragmented and incomplete.
Janna Lynn Fierst
doaj   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

open access: yesMolecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar   +4 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

From Probabilistic to Fuzzy Matching Record Linkage: A promising Transition

open access: yesInternational Journal of Population Data Science
Objective Probabilistic Record Linkage (PRL) heavily relies on manual intervention for gray area resolutions. This makes PRL extremely time and resource intensive. No matter how scientifically sound and robust PRL method is, it didn’t meet close-to-real-
Mahmoud Azimaee   +4 more
doaj   +1 more source

Hierarchical Cluster Analysis: Comparison of Three Linkage Measures and Application to Psychological Data [PDF]

open access: yesTutorials in Quantitative Methods for Psychology, 2015
Cluster analysis refers to a class of data reduction methods used for sorting cases, observations, or variables of a given dataset into homogeneous groups that differ from each other.
Odilia Yim, Kylee T. Ramdeen
doaj  

Evaluating PPRL Vs Clear Text Linkage with Real-World Data

open access: yesInternational Journal of Population Data Science, 2020
Introduction Privacy-preserving Record Linkage (PPRL) is a record linkage technique that can increase the security of personal information. PPRL uses techniques of either hashing identifiers (where exact matches are required) or Blooming identifiers ...
Michael Jarrett   +7 more
doaj   +1 more source

A compilation of LEGO Technic parts to support learning experiments on linkages [PDF]

open access: yesarXiv, 2017
We present a compilation of LEGO Technic parts to provide easy-to-build constructions of basic planar linkages. Some technical issues and their possible solutions are discussed. To solve questions on fine details---like deciding whether the motion is an exactly straight line or not---we refer to the dynamic mathematics software tool GeoGebra.
arxiv  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

OPTIMASI DESAIN MEKANISME LINKAGE GUIDE VANE UNTUK PENGATURAN ALIRAN MASUK AIR KE SUDU PADA TURBIN BANKI

open access: yesJurnal Teknik Pertanian Lampung, 2020
Salah satu bagian penting dalam turbin banki adalah pengaturan guide vane, karena aliran masuk air ke sudu pada turbin tergantung dari pengaturan guide vane nya, baik pada debit rendah maupun normal.
Sirojuddin   +2 more
doaj   +1 more source

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