Results 81 to 90 of about 604,743 (325)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

DLforum – A multidisciplinary online discussion forum for data linkage researchers and practitioners

International Journal of Population Data Science, 2018
Data linkage, the process of identifying records that refer to the same entities across databases, is a crucial component of Population Data Science. Data linkage has a history going back over fifty years with many different methods and techniques being ...
Peter Christen, Thilina Ranbaduge, Dinusha Vatsalan   +2 more
doaj   +1 more source

Advanced nonlinear modelling techniques for switched reluctance machines [PDF]

, 2003
This paper gives an overview of different modelling techniques to describe the nonlinear behaviour of both saturated switched reluctance machine (SRM) and power electronic converter.
Belmans, Ronnie, D'Hulster, Frederik, Desmet, Jan, Stockman, Kurt   +3 more
core  

Food-web structure in relation to environmental gradients and predator-prey ratios in tank-bromeliad ecosystems [PDF]

, 2013
Little is known of how linkage patterns between species change along environmental gradients. The small, spatially discrete food webs inhabiting tank-bromeliads provide an excellent opportunity to analyse patterns of community diversity and food-web ...
A Compin, AJ Gilbert, Alain Dejean, Anna Dornhaus, B Oertli, B Vondracek, BA Richardson, BC Rall, Bruno Corbara, C Fontaine, C Fontaine, C Leroy, CJ Paradise, CR Townsend, Céline Leroy, DM Post, DS Srivastava, G Valladares, GQ Romero, J Bascompte, J Bascompte, J Jabiol, J-F Carrias, J-F Carrias, JA Dunne, Jean-François Carrias, JM Chase, JM Tylianakis, JW Fox, Laurent Pélozuelo, LP Lounibos, M Jocqué, M Kondoh, MA Rodríguez-Gironés, NAC Marino, O Brouard, O Brouard, Olivier Dézerald, P Armbruster, R Céréghino, R Céréghino, RL Vannote, Régis Céréghino, S Declerck, S Drakare, TJ Givnish, WA Ryberg   +46 more
core   +5 more sources

Comparison of record linkage software for deduplicating patient identities in California's Prescription Drug Monitoring Program [PDF]

, 2023
Susan L. Stewart, Andrew J. Crawford, Aaron B. Shev, Garen J. Wintemute, Iraklis Erik Tseregounis, Stephen G. Henry   +5 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Going open source: some lessons learned from the development of OpenRecLink

Cadernos de Saúde Pública, 2015
Record linkage is the process of identifying and merging records across different databases belonging to the same entity. The health sector is one of the pioneering areas of record linkage techniques applications.
Kenneth Rochel de Camargo Jr., Claudia Medina Coeli   +1 more
doaj   +1 more source

Effect of linkage disequilibrium on inferences of population structure and introgression of iberian and black honey bees [PDF]

, 2012
Identification of population structure, a primary goal in population genetics, is easily performed because there is a number of methods available, implemented by user-friendly software packages.
Chávez-Galarza, Julio, De la Rúa, Pilar, Henriques, Dora, Johnston, J. Spencer, Kryger, Per, Pinto, M. Alice, Rufino, José   +6 more
core   +1 more source

Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain [PDF]

, 2011
Objectives: The thickness of the brain’s cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated
Anderson eWinkler, David eGlahn, David eGlahn, Elliott eHong, Henry eHolcomb, Jack eKent, Jason eStein, Joanne eCurran, John eBlangero, Melany eCarless, MP eJohnson, Paul eThompson, Peter eKochunov, Peter eKochunov, Peter eKochunov, Rene eOlvera, Shelley eCole, Tom eNichols, Valeria eKochunov   +18 more
core   +5 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source