Results 121 to 130 of about 336,733 (309)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
University-industry linkages and the role of the geographical proximity [PDF]
The main aim of this paper is to exam the local dimension of the university and industry linkages. It is widely recognized in the literature that academic research is an important source of new knowledge to the innovative efforts of the firms.
Renato Garcia +3 more
core
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Endogenous competences and linkages development [PDF]
In this paper we analyze empirically the influence of firms’ endogenous competences in the existence, quality and results of the linkages between firms and different types of agents.
Erbes, Analía +2 more
core
Spatial 6R linkages based on the combination of two Goldberg 5R linkages
, 2016 In this paper, we report the creation of a pair of 6R linkages by combining Goldberg 5R linkages. The new linkages are similar to the Bennett-joint 6R linkages proposed by Mavroidis and Roth.
core +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
, 1980 Because this journal has as one of its main concerns the subject of structural rigidity, the question of the instantaneous deformability of a structure has been considered in statical terms rather than kinematic ones. This article is intended to put forward the kinematician’s treatment of linkage mobility and to relate it to the internal motion ...
openaire +2 more sources
AD-minister, 2010 Este artículo utiliza el concepto de “cadena de valor global” para hacer un análisis de cómo se desarrolla en Colombia el cluster de animaciones 3D. Se argumenta que la participación en cadenas de valor globales trae un impacto positivo al crecimiento y
Sascha Fuerst
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