Results 191 to 200 of about 2,965,598 (238)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

How does the first index mode of birth in public or private hospitals predict subsequent births? A 16-year Australian population-based linked data study. [PDF]

BMJ Open
Peters L, de Jonge A, de Boer M, Downe S, Dahlen HG.   +4 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Impact of the COVID-19 pandemic on hospital-based heart failure care in New South Wales, Australia: a linked data cohort study. [PDF]

BMC Health Serv Res
McIntyre D, Quintans D, Kazi S, Min H, He WQ, Marschner S, Khera R, Nassar N, Chow CK.   +8 more
europepmc   +1 more source

Pre-diagnostic prescription patterns in bladder and renal cancer: a longitudinal linked data study. [PDF]

Br J Gen Pract
Funston G, Moullet M, Mounce L, Lyratzopoulos G, Walter FM, Zhou Y.   +5 more
europepmc   +1 more source

Quantitative CT imaging characteristics of patients with chronic obstructive pulmonary disease with different eosinophil levels: a retrospective observational study using linked data from a tertiary hospital in China. [PDF]

BMJ Open
Du L, Wu X, Zhao S, Wang K, Liu X, Qi S, Wang R.   +6 more
europepmc   +1 more source

Linked Data

, 2014
openaire   +1 more source

Linked data in beeld : Platform Linked Data Nederland

, 2014
Folmer, Erwin Johan Albert, Verdonk, Yvonne   +1 more
openaire   +1 more source