Results 271 to 280 of about 3,705,766 (336)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Effects of small airtime rewards linked to unsolicited text messages on uptake of a tuberculosis self-screening app in South Africa: a randomised trial. [PDF]

BMJ Open
Rich K, Burger R, Boulle A, Goldberg D, Gqada N, Hynek JP, Loff A, Naidoo P, Nair D, von Delft A, Rieger M.   +10 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Integrated Assessment of Percentage α2,3-Linked Sialylated Prostate-specific Antigen and the Prostate Health Index with Magnetic Resonance Imaging for Detection of Clinically Significant Prostate Cancer. [PDF]

Eur Urol Open Sci
Oishi T, Yoneyama T, Miura Y, Hamaya T, Kodama H, Narita T, Mikami J, Fujita N, Okamoto T, Yamamoto H, Imai A, Ohyama C, Hatakeyama S.   +12 more
europepmc   +1 more source

Uma abordagem baseada em linked open data para diversificação de recomendações.

, 2015
Nicholas Belem Leite, Nailson Boaz Costa. Leite   +1 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Food on demand delivery service: from hospitality to hospital - trialling a proof of concept in a specialist children's hospital. [PDF]

BMJ Open Qual
Wray J, Bexson C, Keyser R, Gough P, Rothman B, Oldham G, Taylor A.   +6 more
europepmc   +1 more source

Exploring the role of symptom monitoring in self-management of chronic physical health conditions experienced by women: protocol for a scoping review. [PDF]

BMJ Open
Thompson H, Boivin J, Csontos JK, Jackowich R.   +3 more
europepmc   +1 more source

Linked open data and research knowledge management : an exploratory search and visualization framework

, 2014
Peter Mechant, Mathias Van Compernolle, Anastasia Dimou, Laurens De Vocht, Lieven De Marez   +4 more
openalex   +1 more source