Results 251 to 260 of about 4,236,805 (394)

Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives. [PDF]

RSC Adv
S Abulkhair H.
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Supramolecular Diversity in Bis(acylhydrazone) Crystals: Linker Effects, Polymorphism, and Gelator Assemblies. [PDF]

Cryst Growth Des
Zhao JJ, Pridmore NE, Blundell TJ, Taylor AC, Smith DK, Cosottini N, Screen MA, Hall AV.   +7 more
europepmc   +1 more source

A Universal Geometric Constraint Linking Stationary Optical, Acoustic and Gravitational Fields

Thimoteo, Mario Cesar Garms
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Molecular basis of sodium channel inactivation. [PDF]

Nat Commun
Liu Y, Galpin JD, Ahern CA, Bezanilla F.
europepmc   +1 more source

Written instructions and video instruction link for the Tasso M-20 device.

Jennifer V. Chavez (21354461), Leah Davis Ewart (21354464), Ozair Ilyas (21354467), Delaram Ghanooni (19544562), José E. Diaz (19544565), Lindsay Atkins (19544559), Richard Ramos (21354470), Adriana Hernandez (21354473), Alex Stewart (130306), Keith J. Horovath (21354476), Sabina Hirshfield (64824), Adam W. Carrico (9609407)   +11 more
openalex   +1 more source

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985.

Molecular Pharmaceutics, 2015
R. Elgersma, Ruud G. E. Coumans, T. Huijbregts, W. Menge, J. Joosten, H. Spijker, F. M. D. de Groot, M. V. D. Van der Lee, R. Ubink, D. J. van den Dobbelsteen, D. Egging, Wim H A Dokter, G. Verheijden, J. Lemmens, C. Timmers, P. Beusker   +15 more
semanticscholar   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source