Results 311 to 320 of about 4,110,454 (393)

Bifunctional Catalysis of Aldol Reactions by Foldamer Dihydrazides: Assessment of Conformational Preorganization. [PDF]

J Am Chem Soc
Lampkin PP, Sanders KM, Garman LC, Guzei IA, Gellman SH.   +4 more
europepmc   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Biological Evaluation of Cleavable Linkers in Exatecan-Based Antibody-Drug Conjugates: A Comparative Study of DXd and Exo-Linker Platforms. [PDF]

ACS Omega
Watanabe T, Iwai Y, Shikida N, Stofleth JT, Fujii T, Seki T, Shimbo K, Matsuda Y.   +7 more
europepmc   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Paving the way for future PSMA inhibitors: insights from comparative preclinical evaluations of structure modifications. [PDF]

EJNMMI Radiopharm Chem
Hajduová K, Bendová KD, Petřík M, Benešová-Schäfer M, Schäfer M, Hajdúch M, Nový Z.   +6 more
europepmc   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Linker-GPT: design of Antibody-drug conjugates linkers with molecular generators and reinforcement learning. [PDF]

Sci Rep
Su A, Luo Y, Zhang C, Duan H.
europepmc   +1 more source

The Role of Non-Catalytic Region in Determining the Difference in Efficiency Between Two Cellobiohydrolases Revealed Through a Genetic Approach. [PDF]

J Fungi (Basel)
Yan X, Waghmare PR, Meng X, Zhang J, Ding S, Lei Y, Yue J, Liu G.   +7 more
europepmc   +1 more source

Development of Optimized Exatecan-Based Immunoconjugates with Potent Antitumor Efficacy in HER2-Positive Breast Cancer. [PDF]

J Med Chem
Auvert E, Douez E, Jolivet L, Witkowski T, Jallas AC, Boursin F, Molnar I, Colas C, Wittmann SV, Auriol M, Chezal JM, Aubrey N, Allard-Vannier E, Maisonial-Besset A, Joubert N, Denevault-Sabourin C.   +15 more
europepmc   +1 more source

Toxicity and efficacy of antibody-drug conjugates in advanced solid tumors: a retrospective single-center analysis of clinical trials. [PDF]

ESMO Open
Woodford R, Almarzouq H, Beygozlu N, Cammarota A, Joshi K, Grochot R, Williams A, Swanton C, Fontana E.   +8 more
europepmc   +1 more source