Results 41 to 50 of about 236 (169)
Advanced Science, EarlyView.The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo +6 more
wiley +1 more source
, 2018 북한의 심각한 에너지 문제의 해결은 주민들의 생존권과 직결되는 인권의 문제일뿐만 아니라, 대북지원의 효과성 제고와 북한의 역량발전, 그리고 통일 이후 발전 격차 감소를 위해 긴요한데, 현재까지 에너지 분야의 대북지원은 간헐적으로 미미한 수준에 그치고 있는 상황이다. 본 연구는 북한의 에너지 부족 현황과 신재생에너지의 활용 현황을 살펴보고, 전통적인 에너지 지원보다는 남 남갈등 유발의 소지가 적고 북한의 수용성이 높으며, UN의 지속가능발전목표 ...
허준영, 유진아, 우창빈
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T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Can The Fifth Enlargement Weaken The EU's Development Cooperation? Jean Monnet/Robert Schuman Paper Series Vol.5 No. 24 August 2005 [PDF]
, 2005 [From the introduction]. The European Union (EU) agreed at the European Council meeting in Copenhague on 13 December 2002 to admit 10 new members from Central Europe and the Mediterranean who meet the political and economic criteria for membership ...
Granell, Francisco.
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Advanced Science, EarlyView.ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu +15 more
wiley +1 more source
Rural realities between crisis and normality : livelihood strategies in Angola, 1975-2008
, 2011 In this thesis I examined the ways in which rural people in Huíla province, Angola, have dealt with crises and adapted their livelihoods accordingly. These responses and adaptations to crises are then juxtaposed against the variety of interventions by ...
van Dijkhorst, H.K. +1 more
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Advanced Science, EarlyView.The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob +12 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu +10 more
wiley +1 more source
Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain
Advanced Science, EarlyView.In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun +27 more
wiley +1 more source
[[alternative]]A Study on EU' Linking Relief, Rehabilitation and Development--The Case of Tajikistan
, 2015 [[abstract]] 歐盟是世界上最大的人道救援捐助者，然而單從緊急人道救援方面著手，只能治標而無法治本。因此除了提供緊急援助外，該如何解決危機的源頭，儼然成為歐盟更應努力的方向。 歐盟強調較好的發展能夠減少緊急救援的需求，較好的緊急救援有助於發展，人道救援及發展援助之間必須有良好的連結，才能提升災民的能力，以應付危機的產生。此外，援助的目標並非只是回到之前的生活，而是希望提供人民更好的生活條件且能保護自己對抗周遭的風險，這也正是LRRD的核心概念。 本論文以LRRD概念之演進為出發點 ...
Cheng, Hsiu-ju, 鄭秀如
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