Results 31 to 40 of about 37,104 (149)

(Apo)Lipoprotein Profiling with Multi‐Omics Analysis Identified Medium‐HDL‐Targeting PSRC1 with Therapeutic Potential for Coronary Artery Disease

open access: yesAdvanced Science, EarlyView.
Lipid content in medium high‐density lipoprotein (HDL) particles, particularly cholesteryl esters, is identified as causally protective of atherosclerosis, and further ASCVD. Evidence from multi‐omics layers of data consistently supports PSRC1 with therapeutic potential for coronary artery disease (CAD), but not ischemic stroke.
Yingmei Li   +8 more
wiley   +1 more source

ProteoSeeker: A Feature‐Rich Metagenomic Analysis Tool for Accessible and Comprehensive Metagenomic Exploration

open access: yesAdvanced Science, EarlyView.
ProteoSeeker is a new metagenomic analysis tool that accelerates protein discovery. By automating key steps, it reduces computational complexity and enables comprehensive dataset analysis, performing protein identification, screening based on user‐defined protein families, and taxonomic analysis.
Georgios Filis   +6 more
wiley   +1 more source

The Dynamic Landscape of 3′‐UTR Alternative Polyadenylation Across Mouse Fetal Development and Anatomy

open access: yesAdvanced Science, EarlyView.
This work maps 3′‐UTR APA across mouse fetal development and tissues, identifying conserved sequence determinants that influence pAS choice. In fetal brain tissues, complex APA dynamics during development are potentially regulated by RBPs like Rbm38, which restrict distal pAS usage.
Qin Wang, Xin Chen, Xiao‐Ou Zhang
wiley   +1 more source

Optimal reactive operation of general topology supply chain and manufacturing networks under disruptions

open access: yesAIChE Journal, EarlyView.
Abstract Supply and manufacturing networks in the chemical industry involve diverse processing steps across different locations, rendering their operation vulnerable to disruptions from unplanned events. Optimal responses should consider factors such as product allocation, delayed shipments, and price renegotiation, among other factors. In such context,
Daniel Ovalle   +6 more
wiley   +1 more source

Morphy: A Compliant and Morphologically Aware Flying Robot

open access: yesAdvanced Intelligent Systems, EarlyView.
This study presents Morphy, a 25.2 cm‐wide, 260 g aerial robot with flexible, sensorized joints that enable it to withstand high‐speed collisions and squeeze through narrow spaces. Powered by an adaptive control scheme exploiting real‐time morphology feedback, Morphy demonstrates resilience in trajectory tracking, collision, and impact recovery and ...
Paolo De Petris   +2 more
wiley   +1 more source

Integrated water resources management: A new strategy for DSS development and implementation

open access: yesRiver, Volume 1, Issue 2, Page 189-206, November 2022., 2022
Abstract Although the recent concept of Integrated Water Resources Management (IWRM) is continuously searching for modern operational approaches to be implemented in practice, the Decision Support Systems (DSSs) have been considered a major effective tool for supporting IWRM.
Qiang Ma, Philippe Gourbesville
wiley   +1 more source

A Hybrid Haptic Device Integrating Pneumatic and Electromagnetic Actuators for Realistic Tactile Signal Feedback

open access: yesAdvanced Intelligent Systems, EarlyView.
A novel soft, wearable haptic device integrates pneumatic and electromagnetic actuators to improve tactile signal transmission. Optimized with finite elements method simulations, it accurately transmits high‐frequency (texture) and low‐frequency (shape) signals. Experimental validation shows its suitability for applications in master–slave robotics and
Youngjun Ryu   +4 more
wiley   +1 more source

A low‐cost protocol for the optical method of vulnerability curves to calculate P50

open access: yesApplications in Plant Sciences, EarlyView.
Abstract Premise The quantification of plant drought resistance, particularly embolism formation, within and across species, is critical for ecosystem management and agriculture. We developed a cost‐effective protocol to measure the water potential at which 50% of hydraulic conductivity (P50) is lost in stems, using affordable and accessible materials ...
Georgina González‐Rebeles   +3 more
wiley   +1 more source

Generation of logic designs for efficiently solving ordinary differential equations on field programmable gate arrays

open access: yesSoftware: Practice and Experience, Volume 53, Issue 1, Page 27-52, January 2023., 2023
Abstract Ordinary differential equations can be used to describe simulation models. As such, solving these equations is an important task in the high performance computing (HPC) domain. Field programmable gate arrays (FPGAs) are a promising platform, expected to be usable as efficient accelerators for such computations.
Silas Bartel, Matthias Korch
wiley   +1 more source

Assessment of ethnic differences in pharmacokinetics and clinical responses of acalabrutinib between Chinese and White patients with B‐cell malignancies

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to assess differences between Chinese and White patients in pharmacokinetics (PK) of, and clinical response to, acalabrutinib and its pharmacologically active major metabolite, ACP‐5862, to support recommended dosing in Chinese patients with B‐cell malignancies.
Tingting Yao   +5 more
wiley   +1 more source

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