Results 71 to 80 of about 811,999 (329)

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

Squamous Cell Carcinoma of the Lip

Česká Stomatologie a Praktické Zubní Lékařství, 2013
Aim of the study: To characterize the current population of patients with squamous cell carcinoma of the lip with focus on the biological behavior and prognosis of these tumors.
L. Hauer, D. Hrušák, L. Hostička, P. Andrle, J. Jambura, P. Pošta   +5 more
doaj   +1 more source

The approximation property for spaces of Lipschitz functions [PDF]

, 2014
Let $\mathrm{Lip}_0(X)$ be the space of all Lipschitz scalar-valued functions on a pointed metric space $X$. We characterize the approximation property for $\mathrm{Lip}_0(X)$ with the bounded weak* topology using as tools the tensor product, the ...
Vargas, Antonio Jiménez
core  

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Probing Hadronization Through Jet Substructure Analysis [PDF]

EPJ Web of Conferences
Understanding the hadronization mechanism in Quantum Chromodynamics (QCD) remains a significant challenge due to its non-perturbative nature. Hadronization is typically described via phenomenological models in Monte Carlo event generators (such as PYTHIA
Apolinário Liliana, Elayavalli Raghav Kunnawalkam, Madureira Nuno Olavo   +2 more
doaj   +1 more source

The prevalence, risk of premature births, mortality and causes of death of cleft lip with or without palate in South Korea: a nationwide population-based cohort study [PDF]

, 2022
Jeong Yeop Ryu, Tae Hyun Park, Byung Chae Cho, Kang Young Choi   +3 more
openalex   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

“C’est possible”. L’autogestione, la LIP e la sinistra

Diacronie. Studi di Storia Contemporanea, 2023
In the summer of 1973, the historical LIP factory of Besançon is occupied and, for several months, managed by the workers themselves. This concretizes the worker’s self-management, an old-standing aspiration in the French worker’s movement, among those ...
Federico DIONISI
doaj  

Universal kinematic scaling as a probe of factorized long-distance effects in high-energy quarkonium production

European Physical Journal C: Particles and Fields, 2018
Dimensional analysis reveals general kinematic scaling rules for the momentum, mass, and energy dependence of Drell–Yan and quarkonium cross sections.
Pietro Faccioli, Carlos Lourenço, Mariana Araújo, João Seixas   +3 more
doaj   +1 more source