Results 141 to 150 of about 53,931 (307)

AKR1C3 Binds β‐Trcp to Promote the Degradation of TFRC to Protect Hepatocellular Carcinoma From Ferroptosis

open access: yesCancer Science, EarlyView.
In this study, we show that aldo‐keto reductase family 1 member C3 (AKR1C3), a protein highly expressed in ferroptosis resistant hepatocellular carcinoma cells, acts as an enzyme‐independent scaffold protein by promoting the nuclear export of β‐transducin repeat protein (β‐TrCP) and its binding to transferrin receptor (TFRC) in an enzyme‐independent ...
Lei Qi   +10 more
wiley   +1 more source

Expanding the Phenotypic Spectrum Associated With Loss‐of‐Function SMARCA4 Variants to Eye Developmental Anomalies

open access: yesClinical Genetics, EarlyView.
This study expands the clinical spectrum of SMARCA4 by describing a novel phenotype in three unrelated individuals with truncating variants. Distinct from Coffin–Siris syndrome and rhabdoid tumor predisposition, this new association is characterized by ocular malformations, specifically microphthalmia and coloboma.
Bertrand Chesneau   +7 more
wiley   +1 more source

Cold plasma treatment for oral lichen planus: a retrospective case collection and proposal of a new clinical score

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Oral lichen planus (OLP) is a chronic autoimmune mucosal disease with malignant potential and limited treatment options. This study evaluated the long‐term efficacy and safety of cold atmospheric plasma (CAP) therapy in therapy‐refractory OLP and introduced the novel Lichen Planus Severity Score (LPSS).
Christian Seebauer   +5 more
wiley   +1 more source

Surgical excision of melanomas in the anal region and reconstruction of the anus in 11 horses

open access: yesEquine Veterinary Education, EarlyView.
Summary This case report describes the surgical excision of large perianal and perineal melanomas, and reconstruction of the anus in 11 grey horses. Four horses had a history of painful defaecation or urination due to extensive tumours. Seven horses had no clinical signs at the time of admission but had rapidly growing nodules around the anus with ...
F. Somm, A. E. Fürst, M. A. Jackson
wiley   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

open access: yesThe FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump   +10 more
wiley   +1 more source

[Coexistence of 4 neoplasms: lymphoma, lip cancer, malignant melanoma and skin cancer in a patient].

open access: yesWiadomosci lekarskie (Warsaw, Poland : 1960), 1990
An extremely rare case is described with coexistence of four neoplasms in one patient diagnosed simultaneously or at short time intervals.
M, Mazurkiewicz, J, Peszyński
openaire   +1 more source

Sex Differences in Health‐Related Quality of Life in Patients With Head and Neck Cancer—A Prospective Study

open access: yesInternational Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective To analyse sex differences in health‐related quality of life (HRQL) before, during and up to 3 months posttreatment of head and neck cancer, and to examine the importance of salivary secretion rate for HRQL posttreatment. Methods Patients were recruited before starting curative oncologic treatment.
Niklas Bohm   +4 more
wiley   +1 more source

Awareness and Usage of Water Irrigation Devices Among Implant Patients: A Cross‐Sectional Study

open access: yesInternational Journal of Dental Hygiene, EarlyView.
ABSTRACT Background Dental implants are a preferred treatment option for partially or completely edentulous patients. However, they come with challenges, such as peri‐implant diseases requiring effective maintenance, including water irrigation devices (WID).
Amal Jamjoom
wiley   +1 more source

Revisiting the mortality of France and Italy with the multiple-cause-of-death approach [PDF]

open access: yes
In this paper, we use the multiple cause-of-death approach to compare the mortality profiles of France and Italy in 2003. Our analysis leads to a substantial re-evaluation of the role played by certain conditions in the process leading to death ...
Aline Desesquelles   +6 more
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