Results 21 to 30 of about 21,561 (262)
LIPA-α-syn inclusions, but not LIPA-α-synΔNAC overexpression, disrupt nigrostriatal neuronal transmission.
, 2022 Representative heat maps of Ca2+ signals in one animal overexpressing (A) LIPA-α-syn exposed to blue light, (B) LIPA-α-syn without light stimulation, and (C) LIPA-α-synΔNAC exposed to blue light.Raquel Rodriguez-Aller (12219304), Maxime Teixeira (12219307), Manel Dahmene (12219322), Jérôme Lamontagne-Proulx (12219328), Wen Luo (513300), Esther Del Cid-Pellitero (12219334), Edward A. Fon (9696880), Jae-Woong Jeong (1674769), Roxanne Turmel (12219313), Thomas M. Durcan (6805865), Morgan Bérard (12219298), Walid Idi (12219310), Marie-Kim St-Pierre (5475677), Denis Soulet (105611), Marilyn Dubois (12219319), Luc Vallières (569534), Charleen Salesse (9203759), Razan Sheta (3825544), Melanie Alpaugh (12219316), Martin Lévesque (5056685), Raza Qazi (12219337), Francesca Cicchetti (8663292), Marie-Eve Tremblay (3424943), Armen Saghatelyan (277651), Omid Tavassoly (12219331), Sarah Malvaut (12219301), Abid Oueslati (816135) +26 morecore +1 more sourceLIPA-α-syn aggregation disrupts nigrostriatal neuronal transmission.
, 2022 (A) Schematic representation of the in vivo experimental paradigm of light-induced α-syn aggregation in the SNc and Ca2+ imaging in the striatum. (B) Confocal microscopy image reconstitution of a sagittal brain slice illustrating the expression of LIPA-α-Raquel Rodriguez-Aller (12219304), Maxime Teixeira (12219307), Manel Dahmene (12219322), Jérôme Lamontagne-Proulx (12219328), Wen Luo (513300), Esther Del Cid-Pellitero (12219334), Edward A. Fon (9696880), Jae-Woong Jeong (1674769), Roxanne Turmel (12219313), Thomas M. Durcan (6805865), Morgan Bérard (12219298), Walid Idi (12219310), Marie-Kim St-Pierre (5475677), Denis Soulet (105611), Marilyn Dubois (12219319), Luc Vallières (569534), Charleen Salesse (9203759), Razan Sheta (3825544), Melanie Alpaugh (12219316), Martin Lévesque (5056685), Raza Qazi (12219337), Francesca Cicchetti (8663292), Marie-Eve Tremblay (3424943), Armen Saghatelyan (277651), Omid Tavassoly (12219331), Sarah Malvaut (12219301), Abid Oueslati (816135) +26 morecore +1 more sourceEffect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single‐center observational study
Pharmacology Research & Perspectives, 2021 Lysosomal acid lipase deficiency (LAL‐D) is an autosomal recessive disease characterized by hypoalphalipoproteinemia, mixed hyperlipemia, and fatty liver (FL) due to mutations in LIPAse A, lysosomal acid type (LIPA) gene.Andrea Pasta, P. Borro, A. Cremonini, E. Formisano, G. Tozzi, S. Cecchi, R. Fresa, S. Labanca, A. Djahandideh, S. Sukkar, A. Picciotto, L. Pisciotta +11 moresemanticscholar +1 more sourceLIPA-α-syn inclusions recapitulate authentic LB features in cell culture.
, 2022 (A) Confocal images of HEK-293T cells overexpressing LIPA-α-syn exposed to blue light for 12 hours (0.8 mW/mm2) and stained with LB markers: α-syn (BDlab), phosphorylated α-syn at S129 (pS129), ThS, ubiquitin, HSP70, and p62 (n = 5) (scale bar = 10 μm). (Raquel Rodriguez-Aller (12219304), Maxime Teixeira (12219307), Manel Dahmene (12219322), Jérôme Lamontagne-Proulx (12219328), Wen Luo (513300), Esther Del Cid-Pellitero (12219334), Edward A. Fon (9696880), Jae-Woong Jeong (1674769), Roxanne Turmel (12219313), Thomas M. Durcan (6805865), Morgan Bérard (12219298), Walid Idi (12219310), Marie-Kim St-Pierre (5475677), Denis Soulet (105611), Marilyn Dubois (12219319), Luc Vallières (569534), Charleen Salesse (9203759), Razan Sheta (3825544), Melanie Alpaugh (12219316), Martin Lévesque (5056685), Raza Qazi (12219337), Francesca Cicchetti (8663292), Marie-Eve Tremblay (3424943), Armen Saghatelyan (277651), Omid Tavassoly (12219331), Sarah Malvaut (12219301), Abid Oueslati (816135) +26 morecore +1 more sourceLIPA-α-syn aggregation disrupts nigrostriatal transmission.
, 2022 Endoscopic live imaging of striatal neurons infected with AAV-CAG-GCaMP6s in freely behaving mice before, during, and after induction of LIPA-α-syn aggregates in the midbrain. (MP4)Raquel Rodriguez-Aller (12219304), Maxime Teixeira (12219307), Manel Dahmene (12219322), Jérôme Lamontagne-Proulx (12219328), Wen Luo (513300), Esther Del Cid-Pellitero (12219334), Edward A. Fon (9696880), Jae-Woong Jeong (1674769), Roxanne Turmel (12219313), Thomas M. Durcan (6805865), Morgan Bérard (12219298), Walid Idi (12219310), Marie-Kim St-Pierre (5475677), Denis Soulet (105611), Marilyn Dubois (12219319), Luc Vallières (569534), Charleen Salesse (9203759), Razan Sheta (3825544), Melanie Alpaugh (12219316), Martin Lévesque (5056685), Raza Qazi (12219337), Francesca Cicchetti (8663292), Marie-Eve Tremblay (3424943), Armen Saghatelyan (277651), Omid Tavassoly (12219331), Sarah Malvaut (12219301), Abid Oueslati (816135) +26 morecore +1 more sourceImage Processing Application for Lipa Saqbe Mandar [PDF]
, 2022 Seeing from today's technological developments, it is growing rapidly, but there are still many people, especially the younger generation today, whose understanding is still very lacking, in recognizing any motifs or patterns in Lipa Saqbe Mandar.Sarjan, Muhammad, Qashlim, Akhmad, Ochtavia, Gustia +2 morecore +2 more sourcesMelanoma-Derived Exosomal miR-125b-5p Educates Tumor Associated Macrophages (TAMs) by Targeting Lysosomal Acid Lipase A (LIPA)
Cancers, 2020 Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment, promoting tumor initiation, growth, progression, metastasis, and immune evasion.D. Gerloff, J. Luetzkendorf, R. Moritz, T. Wersig, K. Mäder, L. Müller, C. Sunderkötter +6 moresemanticscholar +1 more sourceLIPA-α-syn seeds the aggregation of α-syn-GFP.
, 2022 HEK-293T cells overexpressing LIPA-α-syn and α-syn-GFP constructs and exposed to blue light (456 nm, 0.8 mW/mm2) for 12 hours and fixed in 4% PFA. Z-stack confocal imaging and animation rendering with Imaris software showing the seeding effect of LIPA-α ...Raquel Rodriguez-Aller (12219304), Maxime Teixeira (12219307), Manel Dahmene (12219322), Jérôme Lamontagne-Proulx (12219328), Wen Luo (513300), Esther Del Cid-Pellitero (12219334), Edward A. Fon (9696880), Jae-Woong Jeong (1674769), Roxanne Turmel (12219313), Thomas M. Durcan (6805865), Morgan Bérard (12219298), Walid Idi (12219310), Marie-Kim St-Pierre (5475677), Denis Soulet (105611), Marilyn Dubois (12219319), Luc Vallières (569534), Charleen Salesse (9203759), Razan Sheta (3825544), Melanie Alpaugh (12219316), Martin Lévesque (5056685), Raza Qazi (12219337), Francesca Cicchetti (8663292), Marie-Eve Tremblay (3424943), Armen Saghatelyan (277651), Omid Tavassoly (12219331), Sarah Malvaut (12219301), Abid Oueslati (816135) +26 morecore +1 more sourceLIPA-α-syn-induced inclusions recapitulate authentic LB features in the striatum.
, 2022 (A) Experimental design of the overexpression and induction of LIPA-α-syn aggregation in the striatum of WT mice. (B) Representative confocal microscopy images of striatal neurons with LIPA-α-syn aggregates exhibiting authentic LB markers: α-syn (BDlab ...Raquel Rodriguez-Aller (12219304), Maxime Teixeira (12219307), Manel Dahmene (12219322), Jérôme Lamontagne-Proulx (12219328), Wen Luo (513300), Esther Del Cid-Pellitero (12219334), Edward A. Fon (9696880), Jae-Woong Jeong (1674769), Roxanne Turmel (12219313), Thomas M. Durcan (6805865), Morgan Bérard (12219298), Walid Idi (12219310), Marie-Kim St-Pierre (5475677), Denis Soulet (105611), Marilyn Dubois (12219319), Luc Vallières (569534), Charleen Salesse (9203759), Razan Sheta (3825544), Melanie Alpaugh (12219316), Martin Lévesque (5056685), Raza Qazi (12219337), Francesca Cicchetti (8663292), Marie-Eve Tremblay (3424943), Armen Saghatelyan (277651), Omid Tavassoly (12219331), Sarah Malvaut (12219301), Abid Oueslati (816135) +26 morecore +1 more sourceLIPA-α-syn inclusions recapitulate authentic LB features in vivo and precipitate dopaminergic neuronal loss and parkinsonian-like motor impairments.
, 2022 (A) Experimental design of the experiments using the overexpression and induction of LIPA-α-syn aggregation in the midbrains of WT mice. (B) Confocal microscopy images of representative midbrain neurons with LIPA-α-syn aggregates exhibiting authentic LB ...Raquel Rodriguez-Aller (12219304), Maxime Teixeira (12219307), Manel Dahmene (12219322), Jérôme Lamontagne-Proulx (12219328), Wen Luo (513300), Esther Del Cid-Pellitero (12219334), Edward A. Fon (9696880), Jae-Woong Jeong (1674769), Roxanne Turmel (12219313), Thomas M. Durcan (6805865), Morgan Bérard (12219298), Walid Idi (12219310), Marie-Kim St-Pierre (5475677), Denis Soulet (105611), Marilyn Dubois (12219319), Luc Vallières (569534), Charleen Salesse (9203759), Razan Sheta (3825544), Melanie Alpaugh (12219316), Martin Lévesque (5056685), Raza Qazi (12219337), Francesca Cicchetti (8663292), Marie-Eve Tremblay (3424943), Armen Saghatelyan (277651), Omid Tavassoly (12219331), Sarah Malvaut (12219301), Abid Oueslati (816135) +26 morecore +1 more source
