Results 191 to 200 of about 74,383 (246)
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang +12 more
wiley +1 more source
Patatin-domain-containing (phospho)lipases under control: Mammalian co-regulators and pathogenic activation mechanisms. [PDF]
Dubey N, Riegler-Berket L, Oberer M.
europepmc +1 more source
Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley +1 more source
Engineering of Nocardioides acrostichi lipase: utilizing natural variation and mutational free energy to alter expression and functional properties. [PDF]
Jaito N +4 more
europepmc +1 more source
ABSTRACT Fecal microbiota transplantation (FMT), a microbiome‐based therapy, shows potential in treating male sexual dysfunction. Research into the influence of FMT on male sexual function has recently garnered increasing attention. This review aims to explore the impact of fecal microbiota transplantation on male sexual function and the underlying ...
Junyi Chen +4 more
wiley +1 more source
Computational and experimental engineering of a <i>Pleurotus citrinopileatus</i> lipases: Structural insights and functional optimization to adapt the hydrolytic profile for cheese applications. [PDF]
Henrich L +5 more
europepmc +1 more source
Abstract Background Pancreatic enzyme insufficiency (PEI) contributes to symptom burden and malnutrition in advanced pancreatic cancer (aPC). We aimed to evaluate the impact of pancreatic enzyme replacement therapy (PERT) on symptom burden and weight during chemotherapy.
Pamela N. Klassen +6 more
wiley +1 more source
LIPL-1 and LIPL-2 are TCER-1-regulated lysosomal lipases with distinct roles in immunity and fertility. [PDF]
Bahr L +13 more
europepmc +1 more source

