Results 221 to 230 of about 107,533 (320)

Liposomal lipid nanoparticles for extrahepatic delivery of mRNA. [PDF]

Nat Commun
Cheng MHY, Zhang Y, Fox K, Leung J, Strong C, Kang E, Chen Y, Tong M, Bommadevara H, Jan E, Ip OYL, Rodríguez-Rodríguez C, Saatchi K, Häfeli UO, Abdolahzadeh A, Witzigmann D, Cullis PR.   +16 more
europepmc   +1 more source

Preserving the Surface Activity of Lung Surfactant Using Soft Nebulization

Small Science, EarlyView.
This study examines the integrity and surface activity of animal‐derived lung surfactant under different nebulizations. Low‐energy nebulization preserves lamellar structures of the surfactant, enhancing rapid spreading and stability in maintaining low surface tension during interface area changes.
Kaili Xie, Thijs Varkevisser, Antoine Deblais, Wes Onland, Anton H. van Kaam, Daniel Bonn, Cees J. M. van Rijn   +6 more
wiley   +1 more source

Membrane Charge Drives the Aggregation of TDP-43 Pathological Fragments. [PDF]

J Am Chem Soc
Corucci G, Vadukul DM, Paracini N, Laux V, Batchu KC, Aprile FA, Pastore A.   +6 more
europepmc   +1 more source

Gold Nanoparticle Adsorption and Uptake are Directed by Particle Capping Agent

Small Science, EarlyView.
This study explores how ligand‐coated gold nanoparticles (NPs) interact with model membranes. Combining atomic force microscopy (AFM) and molecular dynamics (MD) simulations, it shows how coating properties affect adsorption. The AFM‐MD approach offers a predictive platform for nanoparticle design and toxicity, enabling tailored nanomedicine ...
Rashad Kariuki, Rowan Penman, Alexander D. Newbold, Kalpani A. Mirihana, Pierre H. A. Vaillant, Tilly P. Shepherd, Nastaran Meftahi, Gary Bryant, Kislon Voïtchovsky, Claudia Contini, Andrew Hung, Kevion K. Darmawan, Charlotte E. Conn, Saffron J. Bryant, Andrew J. Christofferson, Aaron Elbourne   +15 more
wiley   +1 more source

Synaptophysin accelerates synaptic vesicle fusion by expanding the membrane upon neurotransmitter loading. [PDF]

Sci Adv
Preobraschenski J, Kreutzberger AJB, Ganzella M, Münster-Wandowski A, Kreutzberger MAB, Olsthoorn LHM, Seibert S, Kiessling V, Riedel D, Witkowska A, Ahnert-Hilger G, Tamm LK, Jahn R.   +12 more
europepmc   +1 more source

A Rapid Assessment Approach for Skin Stratum‐Targeted Drug Delivery Systems Using Mass Spectrometry Imaging and Spatial Clustering

Small Science, EarlyView.
This study presents a novel method for rapidly evaluating dermal drug delivery systems (DDSs). Using mass spectrometry imaging and automated data analysis, it visualizes drug distribution within skin layers in under 10 min. Tested with three nanoscale DDSs for antifungal terbinafine, the approach reveals key differences in drug permeation depth and ...
Ravit Yakobi Arancibia, Einav Bentov‐Arava, Anna Morshin, Jhonathan Elia, Hiba Natsheh, Yael Levi‐Kalisman, Rotem Ushki, Anna Elia, Elka Touitou, Katherine Margulis   +9 more
wiley   +1 more source

Development of Receptor-Integrated Magnetically Labeled Liposomes for Investigating SARS-CoV-2 Fusion Interactions. [PDF]

Anal Chem
Banerjee T, Frazier C, Koti N, Yates P, Bowie E, Liermann M, Johnson D, Willis SH, Santra S.   +8 more
europepmc   +1 more source

Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections

Small Science, EarlyView.
This review critically evaluates fluorescent antibiotics as promising agents combining diagnostic precision with therapeutic efficacy. It highlights advances in probe design, chemical conjugation strategies, real‐time imaging applications, selective pathogen detection, and targeted therapy. The potential to combat antimicrobial resistance is discussed,
Tan Phuoc Ton, Richard Bright, Vi Khanh Truong, Krasimir Vasilev   +3 more
wiley   +1 more source

Minimal presynaptic protein machinery governing diverse kinetics of calcium-evoked neurotransmitter release. [PDF]

Nat Commun
Bose D, Bera M, Norman CA, Timofeeva Y, Volynski KE, Krishnakumar SS.   +5 more
europepmc   +1 more source

A Kinetic Model of Antigen‐Dependent IgG Oligomerization and Complement Binding

Small Science, EarlyView.
A kinetic model capable of predicting IgG oligomerization, a key step in activating the classical complement pathway (CCP) of the immune system, is presented. The impacts of IgG subclass, concentration, and antigen density are analyzed using advanced biophysical techniques.
Jürgen Strasser, Nikolaus Frischauf, Lukas Schustereder, Andreas Karner, Sieto Bosgra, Aran F. Labrijn, Frank J. Beurskens, Johannes Preiner   +7 more
wiley   +1 more source