Results 241 to 250 of about 1,686 (274)

Organotellurane-Promoted Mitochondrial Permeability Transition Concomitant with Membrane Lipid Protection against Oxidation

Chemical Research in Toxicology, 2007
Organotelluranes exhibit potent antioxidant properties as well as the ability to react with protein thiol groups and, thereby, they are good models to study the mechanism of the mitochondrial permeability transition (MPT). We evaluated the effects of the concentration of organotelluranes, namely RT-03 and RT-04, on rat liver mitochondria.
Pessoto, Felipe S., Faria, Priscila A., Cunha, Rodrigo L. O. R., Comasseto, Joao V., Rodrigues, Tiago, Nantes, Iseli L.   +5 more
openaire   +3 more sources

Lipid hydroperoxides initiate the autoxidation of sulfite with concomitant production of superoxide

Journal of Free Radicals in Biology & Medicine, 1986
The inhalation of SO2 or the ingestion of beverages or food containing sulfite as a preservative has been associated with exacerbations of obstructive pulmonary disease. In this study it is demonstrated that 15-HPETE, a likely component of the lung's inflammatory response, can initiate the autoxidation of sulfite.
E P, Brestel, W F, Petrone, R A, Cohen
openaire   +2 more sources

An Orcein-Oil Red O Stain for Concomitant Demonstration of Elastic Tissue and Lipid

Stain Technology, 1967
Orcein, 0.5% in 50% isopropanol, 0.5–1 hr, followed by saturated oil red O in isopropanol diluted 3:2 with distilled water, 10–15 min, was used to demonstrate lipids and elastic tissue simultaneously in 10 μ frozen sections of formalin-fixed aortas of the wild African buffalo, showing atherosclerotic lesions.
B, McKinney, M, Riley
openaire   +2 more sources

Lipid-lowering therapy in patients with arterial hypertension with concomitant chronic obstructive pulmonary disease

South Russian Journal of Therapeutic Practice, 2023
Оbjective: in order to evaluate the effects (lipid-lowering, the effect on the endothelial function and oxidative stress) of pitavastatin at a dose of 4 mg in patients with dyslipidemia, arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD) at baseline, after 4 weeks and 12 months of treatment.Material and methods:the prospective ...
N. U. Grigoryeva, M. O. Petrova, E. I. Blokhina   +2 more
openaire   +1 more source

Effects of Concomitant Therapy with Diltiazem on the Lipid Responses to Simvastatin in Chinese Subjects

The Journal of Clinical Pharmacology, 2010
Diltiazem increases systemic exposure to simvastatin via inhibition of CYP3A. This study assessed the impact of this interaction on the lipid‐lowering effects of simvastatin. Chinese patients with hypercholesterolemia were randomized to receive simvastatin 20 mg daily alone or together with diltiazem 60 mg 3 times daily for 4 weeks with a washout ...
Joyce H S, You, Winnie K Y, Chan, Polly F P, Chung, Miao, Hu, Brian, Tomlinson   +4 more
openaire   +2 more sources

Predictors of Adherence to Concomitant Antihypertensive and Lipid-Lowering Medications in Older Adults

Drugs & Aging, 2008
Many older individuals have concomitant hypertension and dyslipidaemia--two conditions that, together with age, increase the risk of adverse cardiovascular events. Adherence to antihypertensive (AH) and lipid-lowering (LL) therapy is therefore particularly important in older patients with concomitant hypertension and dyslipidaemia.To determine patterns
Richard H, Chapman, Allison A, Petrilla, Joshua S, Benner, J Sanford, Schwartz, Simon S K, Tang   +4 more
openaire   +2 more sources

Concomitant production of chitosan and lipids from a newly isolated Mucor circinelloides ZSKP for biodiesel production

Bioresource Technology, 2019
A newly-isolated oleaginous fungus Mucor circinelloides ZSKP concurrently yielded 21.4% lipids and 11.2% chitosan per gram of biomass. Parameters affecting the co-production were identified using Plackett-Burman design and were statistically optimized using Response Surface Methodology, which resulted in a 3-fold improvement in lipid production.
Johnson Tungamirai, Zininga, Adarsh Kumar, Puri, Algasan, Govender, Suren, Singh, Kugen, Permaul   +4 more
openaire   +2 more sources

Does Synchronizing Initiation of Therapy Affect Adherence to Concomitant Use of Antihypertensive and Lipid-Lowering Therapy?

American Journal of Therapeutics, 2009
Although efficacious medications are available to treat hypertension and dyslipidemia, treatment adherence is often poor. This retrospective study evaluated adherence in patients newly initiating antihypertensive (AH) and lipid-lowering (LL) therapies simultaneously versus within 180 days of one another.
Shuchita, Agarwal, Simon S K, Tang, Noah, Rosenberg, Dan, Pettitt, Trent, McLaughlin, Amie, Joyce, J Sanford, Schwartz   +6 more
openaire   +2 more sources

ApoE Mimetic Peptide Reduces Plasma Lipid Hydroperoxide Content with a Concomitant Increase in HDL Paraoxonase Activity

2009
ApoE mimetic peptide possesses the putative receptor binding domain 141-150 (LRKLRKRLLR) of apoE covalently linked to the class A amphipathic helical peptide 18A. It dramatically reduces plasma cholesterol in dyslipidemic mouse and rabbit models. Recycling of apoE mimetic peptide increases the duration of preβ-HDL formation leading to extended anti ...
Geeta, Datta, Manjula, Chaddha, Shaila P, Handattu, Mayakonda N, Palgunachari, Gaurav, Nayyar, David W, Garber, Himanshu, Gupta, C Roger, White, G M, Anantharamaiah   +8 more
openaire   +2 more sources

Pioglitazone induces lipid accumulation in the rat heart despite concomitant reduction in plasma free fatty acid availability

Archives of Biochemistry and Biophysics, 2008
Thiazolidinediones are insulin-sensitizing drugs which have been proved to be effective in the treatment of type 2 diabetes. However, the action of thiazolidinediones on myocardial metabolism is only poorly recognized. Therefore, the aim of our study was to investigate the effects of two-week pioglitazone treatment (3 mg/kg/d) on lipid and carbohydrate
Marcin, Baranowski, Agnieszka, Blachnio-Zabielska, Piotr, Zabielski, Jan, Gorski   +3 more
openaire   +2 more sources