Results 51 to 60 of about 409,007 (260)

Optimization of ivacaftor-loaded solid lipid nanoparticles for solubility enhancement

Frontiers in Pharmacology
BackgroundCystic fibrosis (CF) is a systemic disease which primarily affects pulmonary system, but also extends to different important organs to cause multitude of associated diseases, leading to rise in rate of morbidity and mortality.
Akshay Parihar, Akshay Parihar, Bhupendra G. Prajapati, Bhupendra G. Prajapati, Bhupendra G. Prajapati, Himanshu Paliwal   +5 more
doaj   +1 more source

The abnormal lipid profile in obesity and coronary heart disease (CHD) in Pakistani subjects

Lipids in Health and Disease, 2020
Background Obesity has become global epidemic in the last three decades, whereas Coronary Heart Disease (CHD) still remains the most important cause of mortality in the world.
Shabana, Saleem Ullah Shahid, Sumbal Sarwar   +2 more
doaj   +1 more source

Lipid Patterns and Atherogenesis in Cholesterol-Fed Chickens

Experimental Biology and Medicine, 1957
Summary1) The degree of atheromatosis in the thoracic aortas and brachiocephalic arteries has been compared with plasma lipid pattern in 255 cholesterol-fed cockerels. Correlation was good with all determined variables except α-lipoprotein cholesterol concentration.
D M, TENNENT, H, SIEGEL, G W, KURON, W H, OTT, C W, MUSHETT   +4 more
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The Mediterranean diet and dietary approach to stop hypertension (DASH)-style diet are differently associated with lipid profile in a large sample of Iranian adults: a cross-sectional study of Shahedieh cohort

BMC Endocrine Disorders, 2021
Background The association between the Mediterranean diet (MED) or dietary approach to stop hypertension (DASH) and cardiovascular disease (CVD) risk factors is well-documented.
Monireh Panbehkar-Jouybari, Mehdi Mollahosseini, Amin Salehi-Abargouei, Hossein Fallahzadeh, Masoud Mirzaei, Mahdieh Hosseinzadeh   +5 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Synthesis of Acinetobacter baumannii Lipid A(s) and derivatives and their structure-immunostimulatory activity relationships

Communications Chemistry
Acinetobacter baumannii emerges as one of the most worrisome pathogens causing a majority of hospital-acquired infections worldwide. However, the knowledge of its virulence factors remains obscure, in particular the bacterial lipooligosaccharides (LOS ...
Xin-Ru Li, Janet Jia-Yin Tan, Chiao-Wen Chen, Jhen-Yan Huang, Hsien-Ya Lin, Boon Hee Goh, Keng-Chang Tsai, Chun-Hung Lin, Kwok-Kong Tony Mong   +8 more
doaj   +1 more source

Evaluation of dyslipidemia in type 2 diabetes mellitus

Asian Journal of Medical Sciences, 2015
Back ground: In type 2 diabetes mellitus lipid abnormalities are almost the rule. Dyslipidemia has been noted to play an integral role in the pathogenesis and progression of micro and macrovascular complications in diabetes mellitus patients.
Devendra Pratap Singh Rajput
doaj   +1 more source

Rumen microbial-driven metabolite from grazing lambs potentially regulates body fatty acid metabolism by lipid-related genes in liver

Journal of Animal Science and Biotechnology, 2023
Background Lipid metabolism differs significantly between grazing and stall-feeding lambs, affecting the quality of livestock products. As two critical organs of lipid metabolism, the differences between feeding patterns on rumen and liver metabolism ...
Zhen Li, Xingang Zhao, Luyang Jian, Bing Wang, Hailing Luo   +4 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source