Results 101 to 110 of about 1,821,750 (247)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Alterations in ether lipid metabolism in obesity revealed by systems genomics of multi-omics datasets.

PLoS Biology
Ratios between two metabolites are sensitive indicators of metabolic changes. Lipidomic profiling studies have revealed that plasma ether lipids, a class of glycero- and glycerophospho-lipids with reported health benefits, are negatively associated with ...
Yvette L Schooneveldt, Sudip Paul, Kevin Huynh, Habtamu B Beyene, Nat A Mellett, Gerald F Watts, Joseph Hung, Jennie Hui, John Beilby, John Blangero, Eric K Moses, Jonathan E Shaw, Dianna J Magliano, Marcus M Seldin, Brian G Drew, Anna C Calkin, Corey Giles, Peter J Meikle   +17 more
doaj   +1 more source

The relationship between AusDiab and SAFHS in the odds ratios (T2D) and odds ratios (prediabetes).

, 2013
Logistic regression of T2D and prediabetes on lipid species adjusted for age, sex, waist circumference and SBP were performed in the AusDiab and SAFHS cohorts.
Laura Almasy (28843), Jeremy B. M. Jowett (463914), Peter J. Meikle (54253), Dianna J. Magliano (463913), Jacquelyn M. Weir (280671), Melissa A. Greeve (463909), Narelle Grantham (463912), Anthony G. Comuzzie (43835), Jonathan Shaw (14762), Adam Kowalczyk (90079), Gerard Wong (280673), Christopher K. Barlow (463908), John Blangero (28885), Izhac Haviv (463911), Gemma L. MacIntosh (463910), Joanne E. Curran (104192), Michael C. Mahaney (387814), Paul Zimmet (14761)   +17 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Three phosphatidylcholines as a potential early-diagnostic signature for hyperglycemia in preschool-aged children: a cross-sectional pilot study

Frontiers in Endocrinology
ObjectiveAlthough lipid metabolism dysregulation commonly accompanies elevated blood glucose, lipidomic studies in hyperglycemic children remain limited.
Haifeng Zhang, Jing Wang, Yueguang Lv, Yiying Huang, Yuanyuan Guo, Chang Jiang, Ting Zhang, Gongshu Liu, Fangfang Chen   +8 more
doaj   +1 more source

Schematic representation of lipid-protein co-aggregation at different L/P ratios.

, 2013
α-synuclein alone aggregates to fibrils that form bundles. When aggregation takes place in the presence of lipid vesicles (L/P = 1), fibrillar co-aggregates composed of protein and lipids form. These aggregates arrange into mesh-like tangles. At higher L/
Emma Sparr (405911), Daniel Topgaard (405912), Agnieszka Nowacka (405909), Erik Hellstrand (469864), Sara Linse (62281)   +4 more
core   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source