Results 91 to 100 of about 16,730 (235)

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

An Insight into the Triabin Protein Family of American Hematophagous Reduviids: Functional, Structural and Phylogenetic Analysis

Toxins, 2016
A transcriptomic analysis of the saliva of T. pallidipennis together with a short proteomic analysis were carried out to reveal novel primary structures of the lipocalin/triabin protein families in this reduviid.
María J. Hernández-Vargas, Carlos E. Santibáñez-López, Gerardo Corzo   +2 more
doaj   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Function, mechanism and evolution of the moubatin-clade of soft tick lipocalins

Insect Biochemistry and Molecular Biology, 2008
The “moubatin-clade” of soft tick lipocalins, although monophyletic show clear signs of paralogy as indicated by the various functions associated with this protein family.
B. Mans, J. Ribeiro
semanticscholar   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, EarlyView.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Tear Lipocalin: structure and Function [PDF]

The Ocular Surface, 2011
Lipocalins are a family of diverse low molecular weight proteins that act extracellularly. They use multiple recognition properties that include 1) ligand binding to small hydrophobic molecules, 2) macromolecular complexation with other soluble macromolecules, and 3) binding to specific cell surface receptors to deliver cargo. Tear lipocalin (TLC) is a
openaire   +2 more sources

Catheter‐Associated Urinary Tract Infections in Children: An Evidence‐Informed Narrative Review of Diagnosis, Management and Prevention

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Catheter‐associated urinary tract infections (CAUTI) are a common healthcare‐associated infection in children and a major contributor to increased morbidity, prolonged hospital stays and higher healthcare costs. This narrative review uses an evidence‐informed approach highlighting recent paediatric literature (2000–2025) to provide an overview
Simon P. Paget, Robert McCusker, Suzanne Simpson, Melissa Short, Angela Berkhout   +4 more
wiley   +1 more source

Clinical Prediction Models for Acute Kidney Injury in Neonatology—A Systematic Review and Modelling Analysis

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aims Acute kidney injury (AKI) affects up to one‐third of neonates admitted to neonatal intensive care units (NICUs). NICUs are highly data‐rich environments, offering opportunities to develop clinical prediction rules (CPRs) that use clinical and demographic data to estimate AKI risk.
Dermot Wildes, Lisa Corley, Deirdre O'Sullivan, David T. Selewski, Caoimhe Costigan, Atif Awan, Catherine Quinlan, Michael A. Boyle   +7 more
wiley   +1 more source

Epididymis-specific lipocalin promoters

Asian Journal of Andrology, 2007
Our goal is to decipher which DNA sequences are required for tissue-specific expression of epididymal genes. At least 6 epididymis-specific lipocalin genes are known. These are differently regulated and regionalized in the epididymis. Lipocalin 5 (Lcn5 or mE-RABP) and Lipocalin 8 (Lcn8 or mEP17) are homologous genes belonging to the epididymis-specific
Suzuki, Kichiya, Yu, Xiuping, Chaurand, Pierre, Araki, Yoshihiko, Lareyre, Jean-Jacques, Caprioli, R.M., Orgebin-Christ, Marie-Claire, Matusik, R.J.   +7 more
openaire   +5 more sources