Lipid Metabolism and Comparative Genomics [PDF]
, 2006 Unilever asked the Study Group to focus on two problems. The first concerned dysregulated lipid metabolism which is a feature of many diseases including metabolic syndrome, obesity and coronary heart disease.
Jones, Janette +5 more
core
Anti-inflammatory and antioxidant properties of HDLs are impaired in type 2 diabetes. [PDF]
, 2011 ObjectiveIn mice, 4F, an apolipoprotein A-I mimetic peptide that restores HDL function, prevents diabetes-induced atherosclerosis. We sought to determine whether HDL function is impaired in type 2 diabetic (T2D) patients and whether 4F treatment improves
Boldrini, Beatrice +7 more
core +1 more source
Concentration of low-density lipoproteins (LDL) is significantly reduced after nilotinib discontinuation. [PDF]
Sci Rep, 2023 Roa-Chamorro R +6 more
europepmc +1 more source
Urinary cholesterol: its association with a macromolecular protein- lipid complex [PDF]
, 1984 The cholesterol-containing complexes in the urine of normal subjects and patients with diseases accompanied by hyperexcretion of urinary cholesterol were characterized. In normal subjects, the major portion of the recovered urinary cholesterol was eluted
Jüngst, Dieter +3 more
core
Bayesian modelling for binary outcomes in the Regression Discontinuity Design [PDF]
arXiv, 2016 The Regression Discontinuity (RD) design is a quasi-experimental design which emulates a randomised study by exploiting situations where treatment is assigned according to a continuous variable as is common in many drug treatment guidelines. The RD design literature focuses principally on continuous outcomes.
arxiv
Fluid-structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery. [PDF]
Sci Rep, 2021 Chen X, Zhuang J, Huang H, Wu Y.
europepmc +1 more source
Regression Discontinuity Designs: A Decision Theoretic Approach [PDF]
arXiv, 2016 The regression discontinuity design (RDD) is a quasi-experimental design that can be used to identify and estimate the causal effect of a treatment using observational data. In an RDD, a pre-specified rule is used for treatment assignment, whereby a subject is assigned to the treatment (control) group whenever their observed value of a specific ...
arxiv
Reduction and simultaneous doping of graphene oxide to repel LDL in treatment of atherosclerosis disease [PDF]
arXiv, 2019 Atherosclerotic disease develops when there is endothelial dysfunction, making low density lipoproteins (LDL) which are cholesterol carriers traveling in the blood, very likely to penetrate the endothelium layer triggering the formation of the atheromatous plaque and leading to the obstruction of blood vessels.
arxiv
Blood lipoproteins shape the phenotype and lipid content of early atherosclerotic lesion macrophages: a dual-structured mathematical model [PDF]
arXivMacrophages in atherosclerotic lesions exhibit a spectrum of behaviours or phenotypes. The phenotypic distribution of monocyte-derived macrophages (MDMs), its correlation with MDM lipid content, and relation to blood lipoprotein densities are not well understood.
arxiv
Designed Sampling from Large Databases for Controlled Trials [PDF]
arXiv, 2015 The increasing prevalence of rich sources of data and the availability of electronic medical record databases and electronic registries opens tremendous opportunities for enhancing medical research. For example, controlled trials are ubiquitously used to investigate the effect of a medical treatment, perhaps dependent on a set of patient covariates ...
arxiv