Results 71 to 80 of about 40,732 (277)

Phase Ib/II Study of the Safety and Efficacy of Combination Therapy with Multikinase VEGF Inhibitor Pazopanib and MEK Inhibitor Trametinib In Advanced Soft Tissue Sarcoma. [PDF]

, 2017
Purpose: Pazopanib, a multireceptor tyrosine kinase inhibitor targeting primarily VEGFRs1–3, is approved for advanced soft tissue sarcoma (STS) and renal cell cancer. Downstream of VEGFR, trametinib is an FDA-approved MEK inhibitor used for melanoma.
Azad, Nilofe A., Kurzrock, Razelle, Ludwig, Joseph A., Meric-Bernstam, Funda, Meyer, Christian, O\u27Connor, Ashley, Roszik, Jason, Shaw, Kenna, Subbiah, Vivek, Zahurak, Marianna L., Zinner, Ralph G.   +10 more
core   +1 more source

Pleomorphic Leiomyosarcoma of the Jejunoileal Mesentery: A Histopathological Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Gastrointestinal leiomyosarcomas are rare malignancies. Herein, we present a case report of a previously healthy 60‐year‐old female presenting with periumbilical abdominal pain, vomiting, and difficulty in passing stool, with clinical workup, imaging, and surgery defining a small intestine tumor.
George S. Stoyanov, Zlatko Zlatev, Andrea Kirilova, Kristina Naydenova, Hristo Popov   +4 more
wiley   +1 more source

Atypical Lipomatous Tumor of the Tongue:Report of a Case [PDF]

, 2010
The term atypical lipomatous tumor (ALT) is synonymous with well-differentiated liposarcoma (WDL). This tumor occurs very rarely in the tongue. Thus, it is difficult to predict its prognosis. Although recurrence of ALT/WDL is thought to be unlikely after
Iida, Seiji, Ikeya, Yoko, Matsumura, Tatsushi, Mishima, Katsuaki, Mizobuchi, Koichi, Moritani, Norifumi, Wakimoto, Mari, Yamada, Tomohiro   +7 more
core   +1 more source

How to Operate on a Huge Intrathoracic Mass? A Practical New Classification and a Special Innovative Surgical Method for the Operation of Huge Intrathoracic Masses

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Huge intrathoracic masses occupying over half of the hemithorax and adhering to multiple thoracic surfaces can be safely resected using a surface‐based classification and targeted rib resection strategy, which enables optimal access, avoids fragmentation, and facilitates en‐bloc tumor removal.
Mohammad Reza Farahnak, Muhammad Sina Salimikouchi, Mohammad Javad Najafzadeh, Amir Baniasad   +3 more
wiley   +1 more source

A highly adhesive and melatonin-loaded PEG hydrogel prevents tumor recurrence and promotes wound healing for tumor-resection wound management of liposarcoma

Materials Today Bio
Liposarcoma is the most common soft tissue sarcoma, and the surgical resection is the primary treatment. However, liposarcoma recurrence and delayed wound healing remain critical challenges due to extensive surgical interventions.
Yonghui Liang, Jianyang Shan, Chen Tan, Zhen Pan, Zhaohui Li, Xiang Fei, Gen Wen, Qingcheng Yang, Dongdong Cheng   +8 more
doaj   +1 more source

Neoadjuvant chemotherapy for soft‐tissue sarcoma of the extremities: A post‐hoc Sarculator‐based risk analysis of the EORTC 62961–ESHO 95 randomized trial

Cancer, Volume 132, Issue 9, 1 May 2026.
Abstract Background In the EORTC 62961–ESHO 95 randomized trial (European Organization for Research and Treatment 62961–European Society of Hyperthermia Oncology 95; ClinicalTrials.gov identifier NCT00003052), neoadjuvant chemotherapy (NAC) combined with regional hyperthermia (RHT) improved survival in patients with soft tissue sarcoma (tumor size >5 ...
Markus Albertsmeier, Valeria Milani, Lars H. Lindner, Gabriele Tinè, Sandro Pasquali, Dario Callegaro, Alessandro Gronchi, Hans‐Roland Dürr, Alexander Klein, Dorit Di Gioia, Sultan Abdel‐Rahman, Michael Schmidt, Jens Werner, Michael von Bergwelt‐Baildon, Rosalba Miceli, Rolf Issels   +15 more
wiley   +1 more source

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. [PDF]

, 2016
Overexpression and/or hyperactivation of cyclin-dependent kinases (CDKs) are common features of most cancer types. CDKs have been shown to play important roles in tumor cell proliferation and growth by controlling cell cycle, transcription, and RNA ...
Duan, Zhenfeng, Hornicek, Francis J, Kan, Quancheng, Shen, Jacson K, Zhou, Yubing   +4 more
core   +1 more source

The first case of rectal myxoid liposarcoma identified by FUS-DDIT3 fusion, presenting as a submucosal tumor with erosion

Human Pathology: Case Reports, 2018
We experienced a 58-year-old Japanese female complaining of bleedings at defecation for about one year. Endoscopy revealed an Ip submucosal tumor (SMT) at the rectum.
Hiroshi Kono, Yoshitane Tsukamoto, Shohei Matsuo, Hideki Hashidate, Hiroyuki Shibuya, Takashi Kobayashi, Yasumasa Takii, Seiichi Hirota   +7 more
doaj   +1 more source

Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Retroperitoneal sarcoma cells can secrete prolactin into the bloodstream, inducing hyperprolactinaemia, which subsequently triggers metabolic reprogramming, such as glucose metabolism. SOX4 can function as a transcription factor that facilitates PRL transcription.
Fu'an Xie, Lingwei Gu, Kunrong Yang, Shuai Wang, Mengmeng Xiao, Guangting Yan, Quan Zhang, Rubing Liang, Aobo Zhuang, Zhe Xi, Yujia Niu, Yanhua Chen, Xiaogang Xia, Linlin Qu, Bin Zhao, Weibing Li, Ting Wu, Chundong Yu, Chenghua Luo, Houzhao Wang, Lanlan Lian, Wengang Li   +21 more
wiley   +1 more source

Adrenal lipomatous tumours: a 30 year clinicopathological experience at a single institution [PDF]

, 2001
AIMS: Fatty tumours of the adrenal gland are uncommon and their features have received little attention in the literature. The aim of this study is to analyse the features of adrenal lipomatous tumours.
Lam, AKY, Lo, CY
core   +1 more source