Results 201 to 210 of about 244,267 (315)

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

open access: yesAdvanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu   +6 more
wiley   +1 more source

Bioorthogonal Reaction of o‐Quinone with Furan‐2(3H)‐One for Site‐Selective Tyrosine Conjugation and Construction of Bispecific Antibody Complexes

open access: yesAdvanced Science, EarlyView.
A site‐selective, efficient, and mild tyrosine conjugation via tyrosinase oxidation and nucleophilic addition, allowing for site‐selective functionalization of peptides, recombinant proteins, and IgGs. Site‐selective mono‐functionalization of IgGs at Y296 enables the construction of immunoliposomes.
Hongfei Chen   +13 more
wiley   +1 more source

Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy

open access: yesAdvanced Science, EarlyView.
In this study, a targeting PFKFB4 biomimetic codelivery system is developed to improve paclitaxel efficacy by inducing ferroptosis in SCLC. This system enhances immune cell infiltration and cytokine secretion, activating anti‐tumor immunity. Combined with anti‐PD‐L1, it boosts immune responses, offering a novel therapeutic strategy for overcoming ...
Xiang Liu   +9 more
wiley   +1 more source

Inhalable Polymeric Nanoparticle Containing Triphenylphosphanium Bromide‐modified Sonosensitizer for Enhanced Therapy of Acute Bacterial Pneumonia

open access: yesAdvanced Science, EarlyView.
Bacterial pneumonia is the sixth leading cause of death. In this study, an inhalable polymeric nanoparticle NPFCPS‐P is developed, which under US stimulation showed high efficacy in the treatment of acute bacterial pneumonia. This nanoplatform would be much less prone to select bacterial resistance and represented a promising measure for antibiotics ...
Lin Wang   +6 more
wiley   +1 more source

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