Results 41 to 50 of about 18,954,287 (311)

Probing molecular motion by double-quantum (13C,13C) solid-state NMR spectroscopy: Application to ubiquitin [PDF]

, 2010
We demonstrate the use of two-dimensional (13C,13C) double-quantum spectroscopy to detect molecular dynamics by solid-state NMR. Data collected on tyrosine-ethylester (TEE) are in line with previously determined (1H,13C) order parameters.
NMR Spectroscopy, Baldus, M., Seidel, K., Schneider, R., Etzkorn, M., Becker, S., Sub NMR Spectroscopy, de Lange, A., Lange, A.   +8 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Recent trends in the impurity profile of pharmaceuticals

Journal of Advanced Pharmaceutical Technology & Research, 2010
Various regulatory authorities such as the International Conference on Harmonization (ICH), the United States Food and Drug administration (FDA), and the Canadian Drug and Health Agency (CDHA) are emphasizing on the purity requirements and the ...
Kavita Pilaniya, Harish K Chandrawanshi, Urmila Pilaniya, Pooja Manchandani, Pratishtha Jain, Nitin Singh   +5 more
doaj   +1 more source

Simultaneous use of solution, solid-state NMR and X-ray crystallography to study the conformational landscape of the Crh protein during oligomerization and crystallization [PDF]

, 2010
We explore, using the Crh protein dimer as a model, how information from solution NMR, solid-state NMR and X-ray crystallography can be combined using structural bioinformatics methods, in order to get insights into the transition from solution to ...
NMR Spectroscopy, Baldus, M., Malliavin, T.E., Etzkorn, M., Böckmann, A., Sub NMR Spectroscopy, Favier, A., Nilges, M., Dep Scheikunde, Bardiaux, B.   +9 more
core  

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Research on porosity characterization methods of shale oil reservoirs in Lianggaoshan Formation, Sichuan Basin

Frontiers in Earth Science
Shale oil, an important component of unconventional oil and gas resources, mainly exists in the storage spaces such as shale pores, microfractures, etc.
Shute Su, Shute Su, Liang Wang, Liang Wang, Jun Li, Jing Lu, Yang Luo, Jun Jia   +7 more
doaj   +1 more source

Solid-state NMR on larger biomolecules [PDF]

, 2011
In the last years, remarkable progress has been made to probe molecular structure of biological systems using Magic Angle Spinning solid-state NMR (ssNMR). Prominent examples relate to research areas that have remained challenging to classical structural
NMR Spectroscopy, Baldus, M., Sub NMR Spectroscopy   +2 more
core  

The PRIMA Thesaurus for Materials Science and Engineering

Advanced Engineering Materials, EarlyView.
The PRIMA Thesaurus is a structured vocabulary designed to improve how materials science data is described and shared. Developed with input from multiple experts, it enables clear documentation of research workflows, data exchange, and reuse across platforms.
Rossella Aversa, Alexey Boubnov, Dario De Angelis, Catriona Eschke, Maximilian Kabbe, Felix Kraus, Mirco Panighel, Richard Thelen, Davide Valentinis   +8 more
wiley   +1 more source

Overhauser enhanced liquid state nuclear magnetic resonance spectroscopy in one and two dimensions

Nature Communications
Nuclear magnetic resonance (NMR) is fundamental in the natural sciences, from chemical analysis and structural biology, to medicine and physics. Despite its enormous achievements, one of its most severe limitations is the low sensitivity, which arises ...
Marcel Levien, Luming Yang, Alex van der Ham, Maik Reinhard, Michael John, Armin Purea, Jürgen Ganz, Thorsten Marquardsen, Igor Tkach, Tomas Orlando, Marina Bennati   +10 more
doaj   +1 more source

Solid-state NMR on complex biomolecules: Methods and applications [PDF]

, 2018
Solid-state NMR (ssNMR) can provide structural information at the most detailed level and, at the same time, is applicable in highly heterogeneous and complex molecular environments, largely irrespective of solubility or crystallinity.
Baldus, Marc, NMR Spectroscopy, Sub NMR Spectroscopy, Weingarth, Markus, Mance, Deni, Webb, Graham A., Marc Baldus, Markus Weingarth, Deni Mance   +8 more
core   +2 more sources