Results 311 to 320 of about 890,337 (369)

Targeted screening and profiling of massive components of colistimethate sodium by two-dimensional-liquid chromatography-mass spectrometry based on self-constructed compound database. [PDF]

J Pharm Anal
Li X, Huang M, Zhao YM, Liu W, Hu N, Zhou J, Wang ZY, Tang S, Pan JB, Lee HK, Yuan YZ, Hang T, Shi HW, Chen H.   +13 more
europepmc   +1 more source

Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation

Advanced Science, EarlyView.
Humanized corneal stroma‐like adhesive patches (HCSPs) are developed for lamellar keratoplasty and corneal perforation repair. HCSPs exhibit histological, optical, and biomechanical characteristics similar to those of the natural cornea, with improved wet tissue adhesion, anti‐degradation, and anti‐swelling capabilities compared to conventional tissue ...
Long Zhao, Zhen Shi, Xiaoyu Zhang, Jingting Wang, Shang Yang, Fuyan Wang, Tan Li, Qingjun Zhou, Ting Wang, Weiyun Shi   +9 more
wiley   +1 more source

BERNN: Enhancing classification of Liquid Chromatography Mass Spectrometry data with batch effect removal neural networks. [PDF]

Nat Commun
Pelletier SJ, Leclercq M, Roux-Dalvai F, de Geus MB, Leslie S, Wang W, Lam TT, Nairn AC, Arnold SE, Carlyle BC, Precioso F, Droit A.   +11 more
europepmc   +1 more source

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

Advanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang, Yi Xie, Shenglong Xia, Xinnuo Ge, Jiaying Li, Fang Liu, Fan Jia, Shengyao Wang, Qiao Zhou, Menghan Gao, Weihuan Fang, Chao Zheng   +11 more
wiley   +1 more source

Studying Venom Toxin Variation Using Accurate Masses from Liquid Chromatography-Mass Spectrometry Coupled with Bioinformatic Tools. [PDF]

Toxins (Basel)
Alonso LL, van Thiel J, Slagboom J, Dunstan N, Modahl CM, Jackson TNW, Samanipour S, Kool J.   +7 more
europepmc   +1 more source

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu, Lili Ji, Yanxia Zhan, Yang Ou, Xia Shao, Xibing Zhuang, Fanli Hua, Feng Li, Hao Chen, Yong Chu, Yunfeng Cheng   +10 more
wiley   +1 more source

Comparison of colorimetric, fluorometric, and liquid chromatography-mass spectrometry assays for acetyl-coenzyme A. [PDF]

Anal Biochem
Kantner DS, Megill E, Bostwick A, Yang V, Bekeova C, Van Scoyk A, Seifert EL, Deininger MW, Snyder NW.   +8 more
europepmc   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Liquid Chromatography-Mass Spectrometry-Based Metabolomics Reveals Dynamic Metabolite Changes during Early Postmortem Aging of Donkey Meat. [PDF]

Foods
Chai W, Wang L, Li T, Wang T, Wang X, Yan M, Zhu M, Gao J, Wang C, Ma Q, Qu H.   +10 more
europepmc   +1 more source

Enhancing Osteogenesis through Bio‐Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production

Advanced Science, EarlyView.
The study highlights the potential of recombinant galaxin (a coral protein) as a novel and effective biomaterial for bone regeneration. It binds to ATP synthase subunit β (ATP5B) in mouse pre‐osteoblasts, thereby causing increased ATP production and mitochondrial activity.
Fei Yu, Xing Zhao, Ting Jiang, Ningjuan Ouyang, Peilin Li, Wei Yang, Zhihe Zhao   +6 more
wiley   +1 more source