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Liquid chromatography-mass spectrometry bottom-up proteomic methods in animal species analysis of processed meat for food authentication and the detection of adulterations.

Mass spectrometry reviews (Print), 2019
This review offers an overview of the current status and the most recent advances in liquid chromatography-mass spectrometry (LC-MS) techniques with both high-resolution and low-resolution tandem mass analyzers applied to the identification and detection
A. Stachniuk   +3 more
semanticscholar   +1 more source

Strategies for large-scale targeted metabolomics quantification by liquid chromatography-mass spectrometry.

In Analysis, 2016
Advances in liquid chromatography-mass spectrometry (LC-MS) instruments and analytical strategies have brought about great progress in targeted metabolomics analysis. This methodology is now capable of performing precise targeted measurement of dozens or
Juntuo Zhou, Yuxin Yin
semanticscholar   +1 more source

Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry.

Mass spectrometry reviews (Print), 2017
In the last decade, the advancement of liquid chromatography mass spectrometry (LC/MS) techniques has enabled their broad application in protein characterization, both quantitatively and qualitatively.
Miao Qu   +7 more
semanticscholar   +1 more source

LaCyTools: A Targeted Liquid Chromatography-Mass Spectrometry Data Processing Package for Relative Quantitation of Glycopeptides.

Journal of Proteome Research, 2016
Bottom-up glycoproteomics by liquid chromatography-mass spectrometry (LC-MS) is an established approach for assessing glycosylation in a protein- and site-specific manner. Consequently, tools are needed to automatically align, calibrate, and integrate LC-
B. Jansen   +6 more
semanticscholar   +1 more source

Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography‐mass spectrometry

Journal of Pineal Research, 1995
: Melatonin, the chief hormone of the pineal gland in vertebrates, is widely distributed in the animal kingdom. Among many functions, melatonin synchronizes circadian and circannual rhythms, stimulates immune function, may increase life span, inhibits ...
R. Dubbels   +7 more
semanticscholar   +1 more source

Analysis of trace levels of sulfonamide and tetracycline antimicrobials in groundwater and surface water using solid-phase extraction and liquid chromatography/mass spectrometry.

Analytical Chemistry, 2001
A method has been developed for the trace analysis of two classes of antimicrobials consisting of six sulfonamides (SAs) and five tetracyclines (TCs), which commonly are used for veterinary purposes and agricultural feed additives and are suspected to ...
M. E. Lindsey, M. Meyer, E. Thurman
semanticscholar   +1 more source

An overview of matrix effects in liquid chromatography-mass spectrometry.

Mass spectrometry reviews (Print), 2011
Matrix-dependent signal suppression or enhancement represents a major drawback in quantitative analysis with liquid chromatography coupled to atmospheric pressure ionization mass spectrometry (LC-API-MS).
H. Trufelli   +3 more
semanticscholar   +1 more source

Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry.

Journal of Proteome Research, 2015
Major depressive disorder (MDD) is a debilitating mental disease with a pronounced impact on the quality of life of many people; however, it is still difficult to diagnose MDD accurately.
Xinyu Liu   +9 more
semanticscholar   +1 more source

Direct identification of rituximab main isoforms and subunit analysis by online selective comprehensive two-dimensional liquid chromatography-mass spectrometry.

Analytical Chemistry, 2015
In this proof-of-concept study, rituximab, which is a reference therapeutic monoclonal antibody (mAb), was characterized through the implementation of online, selective comprehensive two-dimensional liquid chromatography (sLC×LC) coupled with mass ...
D. Stoll   +6 more
semanticscholar   +1 more source

Measurement of in vivo drug load distribution of cysteine-linked antibody-drug conjugates using microscale liquid chromatography mass spectrometry.

Analytical Chemistry, 2014
Analysis of samples containing intact antibody-drug conjugates (ADC) using mass spectrometry provides a direct measurement of the drug-load distribution.
S. Hengel   +5 more
semanticscholar   +1 more source

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