Results 161 to 170 of about 120,161 (290)

ACAT1‐Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
Chemotherapy reduces glucose transporter expression and glucose uptake in cancer cells, leading to decreased pyruvate levels. This decline prompts ACAT1‐mediated acetylation of ME2 at Lys156, enhancing ME2 activity and promoting lactate production from glutamine.
Cuimiao Zheng   +12 more
wiley   +1 more source

Radiosynthesis and Evaluation of [18F]FEHSP990 as Novel PET Tracer for Hsp90 PET Imaging

open access: yesJournal of Labelled Compounds and Radiopharmaceuticals, Volume 68, Issue 4, April 2025.
[18F]FEHSP990 was successfully developed and preclinically evaluated as a novel Hsp90 PET brain probe for tumour and brain imaging. The probe demonstrated high and Hsp90‐specific binding to rodent brain and glioblastoma tumour tissue. In vivo, the tracer showed limited brain exposure, potentially due to insufficient affinity for Hsp90 and/or restricted
Romy Cools   +4 more
wiley   +1 more source

Liquid Scintillation Counting Technique (XI)

open access: yesRADIOISOTOPES, 1975
Yosihiko Kasida, Tetsuo Iwakura
openaire   +2 more sources

A critical step toward far‐field laboratory diffraction contrast tomography in Laue focusing geometry

open access: yesJournal of Applied Crystallography, Volume 58, Issue 2, Page 447-457, April 2025.
A far‐field laboratory diffraction contrast tomography (FF‐LabDCT) technique is established and verified using conventional near‐field LabDCT. Future directions to enhance FF‐LabDCT as a versatile tool are outlined.Recent simulations have demonstrated the promising potential of far‐field laboratory diffraction contrast tomography (FF‐LabDCT) in the ...
Yubin Zhang, Adam Lindkvist
wiley   +1 more source

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