Results 71 to 80 of about 127 (121)
Structural Guidance in 3D Microgel‐in‐Hydrogel Systems to Improve Chondrogenesis
The Anisogel, an anisotropic microgel‐in‐hydrogel system, guides chondrogenic differentiation of human mesenchymal stromal cells (hMSCs) modulated by the alignment and size of anisometric microgels. Chondrogenic markers are upregulated in an in vitro model and guided tissue infiltration is enhanced in a semi‐orthopedic mouse model due to the physico ...
Julia Kamp +12 more
wiley +1 more source
Abstract Mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), remains undiagnosed in > 90% of individuals, delaying access to timely evaluation and interventions. Self‐administered digital cognitive assessments (SA‐DCAs) offer scalable approaches for early detection, yet their real‐world validation and clinical readiness ...
Harald Hampel +10 more
wiley +1 more source
Zn0.03Fe2.97O4 nanoparticles synthesized via a solvothermal route exhibit enhanced magnetic properties and efficient heating under safe clinical limits. This study reveals a synergistic antimicrobial mechanism against thermoresistant P. aeruginosa and C. albicans.
Flavio Cesar Franyutti‐Villegas +7 more
wiley +1 more source
ASK1‐Induced FGF21 Synthesis in the Liver Prevents Obesity in Mice
ABSTRACT Objective Fibroblast growth factor 21 (FGF21) is a stress‐induced hormone secreted by the liver. It has a beneficial role in the regulation of glucose and energy metabolism. Herein, we identify apoptosis signal regulating kinase 1 (ASK1) as an inducer of hepatic FGF21 synthesis.
Anne Goergen +8 more
wiley +1 more source
“I'm a Good Guy Who Deserves Better, Yet Nobody Wants to Give me Better”: The Accounts of Nice Guys
Within Western popular culture and online discourse, a “Nice Guy” is someone who enacts niceness for which they believe they are owed, deserving of, or entitled to something in return—especially the romantic or sexual attention of women. In this study, we examine the use of accounts in personal narratives told in an anonymous online discussion forum ...
Brooke Weinmann, Dennis D. Waskul
wiley +1 more source
Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik +10 more
wiley +1 more source
ABSTRACT Background Family caring roles create significant impacts on individual family members' physical, mental and social wellbeing, and can disrupt family financial stability, relationships and functioning. The perspectives of family members other than mothers are often omitted from research, reducing understanding of the broader impacts of ...
Anneliese de Groot +6 more
wiley +1 more source
Digital assets: risks, regulations, mitigation. [PDF]
Teng HW +30 more
europepmc +1 more source
ABSTRACT Interventions aimed at reducing restrictive practices are also designed to enhance the service experience in acute mental health units. However, people with experience of coercive engagement with these services are seldom involved as active contributors in evaluative research on interventions to reduce restrictive practices.
Esario IV Daguman +4 more
wiley +1 more source

