Results 91 to 100 of about 1,847,399 (293)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Assessing the impact of liquidity creation, ESG performance, and ESG regulation on banking stability

Cogent Economics & Finance
This study examines the relationship between banks’ liquidity creation and banking stability using a two-step System GMM approach on a global bank panel (2014–2023), distinguishing between Advanced Economies (AEs) and Emerging Market and Developing ...
Rendy Pradana Hamidjaya, Dwi Nastiti Danarsari   +1 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Liquidity Creation through Banks and Markets : Multiple Insurance and Limited Market Access [PDF]

The paper surveys theories of the intertemporal allocation of funds through demand deposits and anonymous markets, first separately and then in an integrated model.
Ernst-Ludwig VON THADDEN
core  

CARMEL liquidity indicators of insurance companies [PDF]

Ekonomija: teorija i praksa, 2018
The adoption of guidelines by the National Bank of Serbia in the field of insurance enabled the creation of conditions for a safe and stable insurance market.
Milić Dragana, Matijašević-Obradović Jelena   +1 more
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Housing Wealth, Liquidity Constraints and Self-Employment [PDF]

This paper investigates the existence of liquidity constraints facing entrepreneurs in the United Kingdom. Using a household-level panel data set, entry to selfemployment is shown to be a function of household net worth.
John Gathergood, Richard Disney
core  

Digital Transformation and Bank Liquidity Creation: Evidence From a Bank-Based Market

SAGE Open
This study explores how digital transformation influences the ability of Vietnamese commercial banks to generate liquidity, utilizing panel data from 2007 to 2022.
Japan Huynh
doaj   +1 more source

Liquidity creation and banking stability: an approach using the Bayes method

Cogent Economics & Finance
This research used the Bayesian method and Gibbs sampling algorithm on an unbalanced database and examined the impacts of the liquidity creation (LC) on the financial stability (FS) of the banks in Southeast Asian countries from 2007 to 2021.
Thanh Nga Thi Tran
doaj   +1 more source

International monetary reform and the less developed countries

PSL Quarterly Review, 2014
The present article discusses the implications of international monetary reform for the development of the less developed countries (LDCs). The author first considers liquidity and the proposal for a “link” between monetary reform and the provision of ...
P. STREETEN
doaj   +1 more source