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Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Digital transformation and liquidity creation in commercial banks: Evidence from the Chinese banking industry. [PDF]

PLoS One
Wen W, Liang Y.
europepmc   +1 more source

Inclusive leadership and financial-marketing decision-making in crises: gender diversity and brand resilience. [PDF]

Front Psychol
Javeed A, Khan MY, Alomair A, Al Naim AS.   +3 more
europepmc   +1 more source

Household financial management behavior and catastrophic health expenditure risk in rural China: the moderating role of health insurance coverage. [PDF]

Front Public Health
Cheng Q.
europepmc   +1 more source

LSTM-augmented vine copula modelling for energy-finance contagion analysis. [PDF]

Sci Rep
Zeng L, Huang J, Lin X.
europepmc   +1 more source

The impact of environmental regulation on the development of new quality productive forces in heavily polluting enterprises. [PDF]

Sci Rep
Li S, Lin D, Du B.
europepmc   +1 more source

Income diversification and liquidity risk in ASEAN-5 banks: A Bayesian perspective. [PDF]

PLoS One
Duong QN, Tran NTK, Dang TPT.
europepmc   +1 more source

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Liquidity-constrained index tracking optimization models

Annals of Operations Research, 2021
Miguel Lejeune, Tiago Filomena, Eduardo Bered Fernandes Vieira   +2 more
exaly