Results 41 to 50 of about 22,401 (285)
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Ways Out of Liquidity Trap and Deflation
Acta Universitatis Lodziensis. Folia Oeconomica, 2014 This paper addresses the issue of liquidity trap. The term is adopted from J. Keynes to define an economy in the state of zero bound interest rate and imminent deflation. The discussion is based on findings from P.
Eliza Frejtag-Mika
doaj
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Expectations, Liquidity Trap, and Economic Fluctuations [PDF]
, 2001 The role of the expected interest rate and the expected profit rate in economic fluctuations is examined by focusing on the importance of expectations in households\u27 consumption choices and firms\u27 investment decisions.
Ue Katsuya, 宇惠 勝也
core +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Islamic Economics JournalThis study analyzes the dynamic relationship between Islamic monetary instruments (SBIS, PUAS, and the PLS mechanism) and the distribution of MSME financing in Indonesia, using a Vector Error Correction Model (VECM) for the period January 2014 to ...
M. Habib Ashary +2 more
doaj +1 more source
The Costs of Macroprudential Deleveraging in a Liquidity Trap
IMF Working Papers, 2020 We examine the effects of various borrower-based macroprudential tools in a New Keynesian environment where both real and nominal interest rates are low. Our model features long-term debt, housing transaction costs and a zero-lower bound constraint on policy rates.
Chen, Jiaqian +3 more
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
THE ORIGIN OF FINANCE TOOL FUNCTIONS: COMPULSORY RESERVES
Вестник Российского экономического университета имени Г. В. Плеханова, 2018 The article deals with investigation of an unusual phenomenon, i. e. the origin of compulsory reserve functions as a multifunctional finance tool. Compulsory reserves (compulsory reserve requirements – norms of compulsory reserves) as a finance tool in ...
Tatiana S. Novashina
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source