Results 151 to 160 of about 472,348 (296)
Defining the Clinical Phenotypic Ground Truth: Expert Interrater Agreement in Hyperkinetic Movement Disorders
Movement Disorders Clinical Practice, EarlyView.Abstract Background
Reliable clinical phenotyping is crucial for diagnosis, treatment, and research in hyperkinetic movement disorders, yet its interrater reliability remains uncertain. Objectives
To quantify interrater agreement in clinical phenotyping of hyperkinetic movement disorders among experts in a large, phenotypically diverse cohort.Madelein van der Stouwe, Olof Vermeulen, Wieke Eggink, Tove Henriksen, Eavan McGovern, Marenka Smit, Selma Aybek, Agnita Boon, Rick Brandsma, Andres Deik, Roberto Erro, Alberto Espay, Cristian Falup‐Pecurariu, Stephen Frucht, Christos Ganos, Emilia Gatto, Rick Helmich, Christine Klein, Hans Koelman, Vincent Odekerken, Lisette Koens, Abhimanyu Mahajan, Francesca Morgante, Alexander Münchau, Pattamon Panyakaew, Kathryn Peall, Bélen Pérez‐Dueñas, Emanuel Roze, Anna Sadnicka, Susanne Schneider, Petra Schwingenschuh, Tereza Serranova, Matej Skorvanek, Maria Stamelou, Gertrúd Tamas, Michele Tinazzi, Anna Valadas, Wim Vandenberghe, Jeroen de Vries, Rodi Zutt, Sterre van der Veen, Rogier Luiken, Inge Tuitert, Marina Tijssen +43 morewiley +1 more sourceChallenges of Pain in Parkinson's Disease: Results from the OCEAN Study
Movement Disorders, EarlyView.Abstract Background
Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective
The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.Kallol Ray Chaudhuri, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Monica M. Kurtis, Alexander Storch, José‐Francisco Rocha, Raquel Costa, Diogo Magalhães, Guillermo Castilla‐Fernández, Helena C. Brigas, Joerg Holenz, Per Odin, on behalf of the OCEAN study group +13 morewiley +1 more sourceNeurofilament Light Chain and Mutant Huntingtin Across Huntington's Disease Integrated Staging System Stages in Huntington Disease: A Cross‐Sectional Multimodal Analysis
Movement Disorders, EarlyView.Abstract Background
The Huntington's Disease Integrated Staging System (HD‐ISS) provides a framework for staging HD but does not incorporate fluid biomarkers. Objective
The aim of this study was to examine neurofilament light chain (NfL) and mutant huntingtin (mHTT) and total tau across HD‐ISS stages and their associations with genetic burden ...Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Arnau Puig Davi, Rocío Pérez González, Jordi Pegueroles, Andrea Horta‐Barba, Anna Vázquez Oliver, Elisa Rivas Asensio, Daniel Alcolea, Juan Fortea, Marina Guasch‐Jiménez, Tomas Xuclà Ferrarons, Frederic Sampedro Santaló, Lidia Bojtos, Óscar López‐Lombardía, Ignacio Aracil‐Bolaños, Berta Pascual‐Sedano, Carla Franch Martí, Laura Pérez Carasol, Margarita Rubio Romera, Yi Ji, Alexandre Gironell, Antonia Campolongo, Raul Martínez‐Fernández, Alberto Lleó, Javier Pagonabarraga, Saul Martínez‐Horta, Jaime Kulisevsky, BCN‐HD Working Group;, HDClarity investigators, Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Saül Martínez‐Horta, Arnau Puig‐Davi, Carla Franch, Paula Arranz‐Horno, Oscar López‐Lombardía, Lidia Bojtos, Antonia Campolongo, Javier Pagonabarraga, Jaime Kulisevsky, Asunción Ávila, Nuria Caballol, Alejandro Peral, Jesús Ruíz‐Idiago, Misericordia Floriach, Matilde Calopa, Helena Bejr Kasem, Clara Marzal Espí, Esteban Muñoz, Celia Painous, Irene Navalpotro, Victor Puente, Victoria González, Pau Pastor, Dolores Vilas, Iñigo Ruiz Barrio, Lourdes Ispierto, Eliot Gómez‐López, Claustre Pons, Gracia Pons, Maria Teresa Buongiorno, Anna Mas, Maria Pilar Gil, Jordi Casanovas, Edward Wild, Tiago Mestre, Mark Guttman, Philippe Rizek, Blair Leavitt, Carsten Saft, Bjorn Falkenburger, Juergen Winkler, Ralf Reilmann, Jan Lewerenz, Alzbeta Mühlbäck, Jesús Pérez‐Pérez, Tamara Fernandez Valle, José Luis López‐Sendón Moreno, Christophe Verny, Cyril Goizet, Caterina Mariotti, Ferdinando Squitieri, Tim Anderson, Richard Roxburgh, Grzegorz Witkowski, Leonor Correia Guedes, Hugh Rickards, Elizabeth Coulthard, Roger Barker, Anne Rosser, Tim Harrower, Robert Thompson, James Herron, Jeremy Cosgrove, Rhys Davies, Nayana Lahiri, Richard Armstrong, Daniel Lashley, Jee Bang, Erin Furr‐Stimming, Jessica Tate, Meagen Salinas, Karen Anderson, Amy Brown +104 morewiley +1 more sourceA defesa europeia em Lisboa
, 2010 Como fica a segurança e defesa da ue no Tratado de Lisboa? Esta é uma área tradicionalmente de difícil integração europeia, pois está entre os poderes fundamentais do Estado soberano moderno. Por outro lado, os custos crescentes da defesa, um mundo em que as ameaças podem ser mais difusas, mas não são menos reais, e a crise económica e financeira ...openaire +2 more sourcesAdvancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies
Medicinal Research Reviews, EarlyView.ABSTRACT
The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça +23 morewiley +1 more sourceIntervenção na Manutenção Militar no Beato, Lisboa
, 2017 Dissertação de Mestrado Integrado em Arquitetura, com a especialização em Arquitetura de Interiores e Reabilitação do Edificado, apresentada na Faculdade de Arquitetura da Universidade de Lisboa para obtenção do grau de Mestre.N/Liberato, Maria Nevescore Interdiction Models and Heuristics for Graph Propagation
Networks, EarlyView.ABSTRACT
Given a graph G=(V,E)$$ G=\left(V,E\right) $$ and a set S⊂V$$ S\subset V $$ of activated/infected nodes, we consider the problem of determining the set of c$$ c $$ nodes that minimizes the network propagation on the subgraph that results from the removal of those c$$ c $$ nodes. To measure network propagation, we assume that a node i$$ i $$ is Agostinho Agra, José Maria Samucowiley +1 more sourceCorrection: Oliveira et al. Circulating Inflammatory miRNAs Associated with Parkinson's Disease Pathophysiology. <i>Biomolecules</i> 2020, <i>10</i>, 945. [PDF]
BiomoleculesOliveira SR, Dionísio PA, Correia Guedes L, Gonçalves N, Coelho M, Rosa MM, Amaral JD, Ferreira JJ, Rodrigues CMP. +8 moreeuropepmc +1 more source