Results 181 to 190 of about 7,012,732 (349)

Is a Clinical Trial With a Non‐Bioequivalent Batch Necessary? The Critical Role of Intrasubject Variability in Olaparib Formulation Bridging by PBPK

Clinical Pharmacology &Therapeutics, EarlyView.
Although physiologically based pharmacokinetic (PBPK) modeling is increasingly being used to support oral drug formulation bridging, the acceptance by regulatory agencies is low. One of the primary concerns is the absence of clinical pharmacokinetic (PK) data from a non‐bioequivalent (non‐BE) batch during model validation.
Jin Dong, Andrea Moir, Xavier Pepin, Elizabeth Lowe, Sandy Hopkins, Weifeng Tang, Diansong Zhou   +6 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Structural Properties of Yukawa One‐Component Plasmas Revisited

Contributions to Plasma Physics, EarlyView.
ABSTRACTYukawa one‐component plasmas are fully described in terms of the Coulomb coupling parameter Γ$$ \Gamma $$ and the screening parameter κ$$ \kappa $$. One of their remarkable properties is the existence of lines of constant effective coupling, Γeff(Γ,κ)$$ {\Gamma}_{\mathrm{eff}}\left(\Gamma, \kappa \right) $$, along which their short‐range ...
Daniels Krimans, Hanno Kählert
wiley   +1 more source

What is the Environmental Performance of Firms Overseas?: An Empirical Investigation of the Global Gold Mining Industry [PDF]

Bayesian stochastic frontier analysis; efficiency; environmental regulations and plant performance; pollution havens; regulatory chill; gold mining.
Gary Koop, Lise Tole
core  

Monocyte maturation pattern by flow cytometry expression of CD64, CD300e, and CD14 correlates to presence of myeloid neoplasm and helps identify blast equivalents in the setting of monocytic neoplasm

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract CD300e is a marker of mature monocytes in flow cytometry; however, there is limited detailed information on staining patterns in conjunction with other monocyte markers. We evaluated the flow cytometric staining patterns of CD64, CD14, and CD300e in 12 negative and 33 positive peripheral blood specimens and 16 negative and 56 positive bone ...
Jenny Zhang, Jacob Kaplan, Elizabeth Courville   +2 more
wiley   +1 more source

Sibling Involvement and Documentation in Pediatric Eating Disorder Care

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective When a young person has an eating disorder (ED), the entire family, including siblings, is affected. Despite recommendations in clinical guidelines and treatment manuals to involve and support siblings, little is known about how this is enacted and documented in practice.
Amalie Schumann, Elizabeth Rapa, Louise Dalton   +2 more
wiley   +1 more source

Tick‐Tock, the Time Has Come: Leveraging TikTok to Understand, Prevent, and Treat Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective TikTok—a highly engaging social media platform with a powerful algorithm that displays short videos—has become massively popular in recent years. As research highlights the concerning relationship between image‐based content on social media and disordered eating symptoms, TikTok may serve as an optimal platform to understand eating ...
Macarena Kruger, Isabella Pruscino, Caroline G. Martin, Elizabeth A. Velkoff   +3 more
wiley   +1 more source

Case report: Onychopapilloma in a patient with BAP1 tumor predisposition syndrome-a useful clinical marker? [PDF]

Fam Cancer
Sjøstrøm E, Ahlborn LB, Eliesen EV, Wadt K, Lei U, Byrjalsen A.   +5 more
europepmc   +1 more source

Hot spots or hot moments? Contextualizing the spatio‐temporal scale of research on animal inputs

Ecography, EarlyView.
Mammals play important roles in redistributing elements across ecosystems, concentrating biogeochemical inputs across both space and time. However, research on zoogeochemical inputs is often constrained by logistical considerations, potentially limiting our knowledge of mammals' impacts on biogeochemical patterns and processes.
Kristy M. Ferraro, Elizabeth S. Forbes, Andrew J. Abraham, Julia D. Monk   +3 more
wiley   +1 more source

Commitment to Myogenic Differentiation Significantly Aggravates the RNA Phenotype in Myotonic Dystrophy Type 1. [PDF]

Neuropathol Appl Neurobiol
Ripken L, van den Broek WJAA, van Cruchten RTP, Smits JGA, Riepe TV, 't Hoen PAC, Wansink DG.   +6 more
europepmc   +1 more source