Results 171 to 180 of about 8,759,985 (270)

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Combining the list-experiment and direct question to improve estimation of abortion incidence. [PDF]

Am J Epidemiol
Jackson HM, Rendall MS.
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Posterior Hamstring Harvest and Preparation for Quadruple Autograft All-Inside Anterior Cruciate Ligament Reconstruction. [PDF]

Video J Sports Med
van der List JP, Backs R, Kaeding CC.
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Opioid prescribing to people on orthopaedic waiting lists during the covid-19 pandemic in England: retrospective cohort study using linked electronic health record data in OpenSAFELY-TPP. [PDF]

BMJ Med
Higgins R, Smith RM, Dillingham I, Quinlan J, Speed V, Curtis HJ, Wood C, Wiedemann M, Jani M, Bacon SCJ, Mehrkar A, Goldacre B, Collaborative O, MacKenna B, Schaffer AL.   +14 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Defining chronic ambulatory care sensitive conditions in Malaysia: a collaborative consensus study. [PDF]

BMJ Open
Md Sharif S, Fun WH, Chidambaram SK, Saw PS, Mohd Nasarruddin A, Mohd Fauzi N, Azali A, Jailani AS, Sararaks S.   +8 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Excluding Ascites From the GEMA-Na Score Does Not Impact Outcome Predictions in Liver Transplant Candidates. [PDF]

Liver Int
Rodríguez-Perálvarez ML, Gómez-Orellana AM, Majumdar A, McCaughan GW, Kalafateli M, Taylor R, de la Rosa G, Aguilera MV, Gastaca M, Cepeda-Franco C, Ortiz ML, Colmenero J, Otero A, González Grande R, Cachero A, Molina Pérez E, Barreales M, Martín Mateos R, Rodríguez-Soler M, Romero M, Dopazo C, Alonso Martín C, Otón E, González Diéguez L, Espinosa MD, Arias Milla A, Blanco Fernández G, Lorente S, Cuadrado Lavín A, Sogbe M, Guijo-Rubio D, Hervás Martínez C, Tsochatzis E.   +32 more
europepmc   +1 more source