Results 51 to 60 of about 1,704,319 (230)

Secure top most significant genome variants search: iDASH 2017 competition

BMC Medical Genomics, 2018
Background One of the 3 tracks of iDASH Privacy & Security Workshop 2017 competition was to execute a whole genome variants search on private genomic data.
Sergiu Carpov, Thibaud Tortech
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Papież Celestyn I o świętym Augustynie

Vox Patrum, 1988
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Stanisław Longosz
doaj  

Sposoby radzenia sobie ze stratą bliskiej osoby w narracjach epistolograficznych kobiet

Nauki o Wychowaniu
W niniejszym artykule omówiono wyniki badań jakościowych, których celem była analiza ujawnianych w reakcji na śmierć bliskiej osoby doświadczeń narratorek i mechanizmów ich radzenia sobie z utratą.
Joanna Kajko-Rykalska, Anna Duraj, Dagmara Górecka, Barbara Tkocz, Alina Szweda   +4 more
doaj   +1 more source

Temperature Resistant Fiber Bragg Gratings for On-Line and Structural Health Monitoring of the Next-Generation of Nuclear Reactors

Sensors, 2018
The harsh environment associated with the next generation of nuclear reactors is a great challenge facing all new sensing technologies to be deployed for on-line monitoring purposes and for the implantation of SHM methods.
Guillaume Laffont, Romain Cotillard, Nicolas Roussel, Rudy Desmarchelier, Stéphane Rougeault   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

List jako dokument biograficzny – wspólnota doświadczeń rodzinnych, na podstawie „Listów z Syberii Irki A.”

Nauki o Wychowaniu
Współcześnie, w świecie naznaczonym nowoczesnymi technologiami i możliwościami szybkiej komunikacji, zanika zarówno praktyka pisania listów, jak i oczekiwania na listy.
Joanna Golonka-Legut
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source