Results 191 to 200 of about 17,887 (258)

Spatiotemporal Dynamics in Prespeech Semantic Category Decoding: An Intracranial EEG Study. [PDF]

eNeuro
Park YJ, Kwon J, Lee G, Meng K, Chung CK.   +4 more
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

The Severity of Phonological Deficit as a Determinant of Dyslexia Compensation in Adulthood. [PDF]

Dyslexia
Pellicer-Magraner A, Zarzo-Benlloch M, Ygual-Fernández A, Cervera-Mérida JF.   +3 more
europepmc   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

Flexible Integration of Structurally Diverse Spatial Multi‐Omics With AgaeSMO

Advanced Science, EarlyView.
AgaeSMO is a versatile and robust deep learning framework for flexible cross‐integration of spatial multi‐omics data. Leveraging a GATs network with a graph attention module, it learns joint embedding across diverse modalities, enabling integration of both structurally paired (e.g., spatial transcriptome‐epigenome, transcriptome‐proteome, transcriptome‐
Kunpeng Liu, Jinpo Su, Haotian Zhou, Yilin Shen, Mengke Qin, Yingjie Luo, Tiancai Wang, Zhenglin Chen, Yuanyuan Wang, Xiaokai Ma   +9 more
wiley   +1 more source

Identity-specific reward expectations in orbitofrontal cortex guide goal-directed choices. [PDF]

PLoS Biol
Witkowski PP, Henein N, Moussa N, Schoenbaum G, Kahnt T.   +4 more
europepmc   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Relations of First-Grade Teacher Knowledge with Gains for Students at Risk for Reading Difficulties. [PDF]

Read Writ
Hall C, Solari EJ, DeCoster J, Pellei M, Dahl-Leonard K, Wong VC, Richards-Tutor C, Baker DL, Conner C, Darcy LJ, Wilburn KE, Mallory A, Hayes L.   +12 more
europepmc   +1 more source

LigHTS: Biomimetic Hydrogel Photo‐Fabrication for Imaging‐Based Ultra‐High‐Throughput Screening

Advanced Science, EarlyView.
LigHTS removes a key bottleneck for ultra‐high‐throughput screening (UHTS) by enabling biomimetic hydrogel microenvironments to be manufactured directly in standard multiwell plates. A single, collimated UV exposure with formulation‐tuned light penetration patterns an entire plate with UHTS‐grade uniformity (<20% CV), producing structured GelMA films ...
Alessandro Enrico, Sara Rigolli, Julius Zimmermann, Melissa Pezzotti, Eloisa Torchia, Moises Di Sante, Ferdinando Auricchio, Francesco S. Pasqualini   +7 more
wiley   +1 more source

Reply to: "No evidence of neural feature-specific pre-activation during the prediction of an upcoming stimulus". [PDF]

Nat Commun
Demarchi G, Hartmann T, Hauswald A, Schubert J, Reisinger L, Topalidis P, Benz K, Schmidt F, Gehmacher Q, Weisz N.   +9 more
europepmc   +1 more source