Results 101 to 110 of about 2,728 (287)
Advanced Science, EarlyView.CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi +8 more
wiley +1 more source
Middlebrow Matters: Women’s Reading and the Literary Canon in France since the Belle Époque by Diana Holmes [PDF]
, 2019 Anne O’Neil-Henry
openalex +1 more source
Advanced Science, EarlyView.This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren +11 more
wiley +1 more source
Postscriptum Polonistyczne, 2020 The author poses the question whether Polish literary canon that has been established since Romanticism through translations into French can be used in the joint‑creation of the canon of European literature.
Jadwiga Warchoł
doaj
Al. O. Teodoreanu, hronicul măscăriciului vălătuc sau despre rescrierea istoriei în cheie parodică [PDF]
Revista de Istorie și Teorie Literară, 2016 Hronicul măscăriciului Vălătuc [The Chronicle of Vălătuc the Fool] overtly relates to the literary and bookish pattern of minor discourse, focusing on parody viewed as ante-Postmodern writing strategy used to ironically discredit the major literary canon/
Simona Antofi
doaj
Advanced Science, EarlyView.This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang +9 more
wiley +1 more source
Literary, Found and Research Poetry: New Approaches to Representations of Aging and Aged Care. [PDF]
Gerontologist, 2023 Holland-Batt S, Miller E.
europepmc +1 more source
Advanced Science, EarlyView.A phosphorothioate‐modified aptamer PTf‐SRiApt capable of disrupting “undruggable” transcription factor SCAF4‐POLR2A interaction with high inhibitory activity and biological stability is presented here. Through this inhibition, PTf‐SRiApt successfully arrested cell cycle progression, induced cell death, and elevated immune recruitment in SCAF4‐POLR2A ...
Liyan Fei +13 more
wiley +1 more source