Results 51 to 60 of about 94,855 (316)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Differentiated Instruction and Students’ Literary Competence: An Experimental Study

open access: yesMiddle Eastern Journal of Research in Education and Social Sciences, 2021
Purpose: This study aims to determine the effects of Differentiated Instruction on Catigbian National High School Grade 10 students’ literary competence. Approach/Methodology/Design: To attain that purpose, the researcher adopted the experimental design involving two groups of participants.
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Typothesis: A Study of Warde\u27s Crystal Goblet, Leeuwen\u27s Typographic Meaning and How it Relates to the Bible [PDF]

open access: yes, 2011
The way readers interpret the written word is changing. We look for information almost as much in between the lines as we do in the words themselves. The internet and its tools offer ways for readers to engage the text like never before — can the printed
Mercer, Ryan
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

William Faulkner: calendari, orologi e altri disperati tentativi di dominare il tempo [PDF]

open access: yesImpossibilia: Revista Internacional de Estudios Literarios, 2012
This essay focuses on The Sound and the Fury and the implosion of all temporal cohesionin Faulkner’s novel(s). Up until the beginning of the Twentieth Century, the form of the novelcoincided with narrative form, that is, narrative order, which is perhaps
Donata Meneghelli
doaj  

Methods in Psychological Research [PDF]

open access: yes, 2002
Psychologists collect empirical data with various methods for different reasons. These diverse methods have their strengths as well as weaknesses. Nonetheless, it is possible to rank them in terms of different critieria.
Chow, Siu L.
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

The architectural drawings of Victor Hugo: between reality and reverie

open access: yesEGA, 2014
Victor Hugo was not a painter nor an architect, so the search developed in his drawings was rather conceptual than formal. His drawings seek to go into detail about the creative soul of the artist through the experimentation and the chance; intrusion ...
Jorge Llopis Verdú
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

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