Results 61 to 70 of about 94,855 (316)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Literary Piracy and the Art of Experimental Narratives

open access: yesCultural Intertexts, 2018
A pirate is a ship-raider who abides by no rules. The pirate roams the tides of the ocean exploring new territories. An experimental writer is a literary pirate who explores new textual territories and toys with literary canons. The literary pirate abides by no generic laws and inscribes rebellion in the pages of his fiction.
openaire   +2 more sources

Playground of gender : cross-dressing and self-mutilation as negation of gender identity in Tanja Duckers’s Spielzone (1999) [PDF]

open access: yes, 2014
Although it is an outstanding example of writing life as negotiation of gender roles as well as exploration of the body as site of identity constructs, Tanja Dückers’s novel Spielzone, published in 1999, has not yet received the critical attention it ...
Dautel, Katrin
core  

Multiparty talk in the novel: the distribution of tea and talk in a scene from Evelyn Waugh's Black Mischief [PDF]

open access: yes, 2002
This article argues that studies of fictional dialogue have hitherto neglected the specific dynamics of multiparty talk. I will contend that this neglect contributes to the perpetuation of an "ideal" of conversation that allows no space for either the ...
Thomas, Bronwen
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Introduction

open access: yesÉtudes Britanniques Contemporaines, 2019
This issue of Études britanniques contemporaines aims at questioning the relevance of indexing literariness on a revolutionary aesthetics inherited from the great 20th century avant-gardes.
Catherine Bernard
doaj   +1 more source

Binary synthesis: Goethe's aesthetic intuition in literature and science [PDF]

open access: yes, 2005
Argument This essay seeks to identify the cultural significance of Goethe's scientific writings. He reformulates, in the light of his own concrete experience, “crucial turning-points” (Hauptmomente) in the history of science – key ideas, the ...
Stephenson, R.
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

A contemporary history of circus arts in Buenos Aires, Argentina: the post-dictatorial resurgence and revaluation of circus as a popular art [PDF]

open access: yes, 2015
The purpose of this paper is to study the process of resurgence and redefinition of popular practices promoted in the city ofBuenos Aires,Argentina, in post- dictatorial years, through the case of circus arts.
Infantino, Julieta Lorena
core  

WRITING UTOPIA NOW: Utopian Poetics In The Work Of Theresa Hak Kyung Cha [PDF]

open access: yes, 2020
This thesis examines Theresa Hak Kyung Cha’s DICTEE (1982), Audience Distant Relative (1977) and Reveillé dans la Brume (Awakened in the Mist) (1977). The premise of the thesis is an exploration of the various ways in which these works both perform and ...
Willow, S., Willow, S.
core  

Home - About - Disclaimer - Privacy