Results 81 to 90 of about 94,855 (316)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

La science-fiction et l’expérimentation formelle

ReS Futurae
Science fiction, at least in its earliest mediatic incarnation (literary, but also iconographic, auditory and dramatic in the broadest sense) has long been grounded in the notion of experience, but this is often primarily understood as narrative ...
Jérôme Dutel, Alice Ray
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The Post-War Novel in Crisis: Three Perspectives [PDF]

, 2005
Three major novelists of the period following the second world war, Iris Murdoch, Doris Lessing and V.S. Naipaul, have pondered the question of why the post-war novel is unable to achieve the heights of its nineteenth-century predecessors. Each of these
Dooley, Gillian Mary
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The philosophical meaning of the experimental literary art

NaUKMA Research Papers in Philosophy and Religious Studies
У статті розглянуто форми, характеристики, способи написання та філософське значення експериментальних літературних творів на прикладі авангардистських творів ХХ ст. Метою дослідження було проаналізувати форми і функції експериментального мистецтва з погляду представників модерної філософії.
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Genre Classification of Books in Russian with Stylometric Features: A Case Study

Information
Within the literary domain, genres function as fundamental organizing concepts that provide readers, publishers, and academics with a unified framework.
Natalia Vanetik, Margarita Tiamanova, Genady Kogan, Marina Litvak   +3 more
doaj   +1 more source

Early English meter as a way of thinking

Studia Metrica et Poetica, 2017
The second half of the fourteenth century saw a large uptick in the production of literature in English. This essay frames metrical variety and literary experimentation in the late fourteenth century as an opportunity for intellectual history.
Eric Weiskott
doaj   +1 more source

Animal Abilities: Disability, Species Difference, and American Literary Experimentation

, 2020
Disability and animality have frequently been conjoined in American literature as the limit cases of cognition, language, and narrative. In modern and contemporary fiction, this intersection is not just thematic, but also an opportunity for formal experimentation.
openaire   +2 more sources