Results 81 to 90 of about 5,429,905 (405)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Towards a computational history of modernism in European literary history: Mapping the Inner Lives of Characters in the European Novel (1840-1920). [PDF]

open access: yesOpen Res Eur, 2023
Radak T   +9 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Willy Haas (1891-1973) : "homme de lettre" [PDF]

open access: yes, 2011
There are many aspects of Haas' life and experiences in India which deserve greater attention. I would like to refer briefly only to his attempts as a litterateur to come to terms with 'India' as presented in his autobiographical recollection and to some
Bhatti, Anil
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

PARALLELED CHARACTERS IN THE DRAMATIC WORKS OF HORTENSIA PAPADAT-BENGESCU [PDF]

open access: yesDiversitate si Identitate Culturala in Europa, 2015
This article proposes a psychoanalytical approach to two paralleled literary characters whom Hortensia Papadat-Bengescu places into opposition in order to introduce her readers to feminine hypostases of wish fulfilment.
Simona GALAŢCHI
doaj  

Rethinking the History of the Literary Symposium [PDF]

open access: yes, 1992
published or submitted for ...
Greek Seminar 420 Spring 1992 UIUC   +1 more
core  

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