Results 61 to 70 of about 407,634 (309)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
, 2017 The article is concerned with the role of St. Clement’s Church in the preservation and the spread of Cyril and Methodius’s literary tradition and Slavic church services.
Pop-Atanasov, Gjorgi
core
Understanding copyright in support of scholarship: some possible challenges to scholars and academic librarians in the digital environment? [PDF]
, 2009 This is the author’s version of a work that was accepted for publication of the article: International Journal of Information Management. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and
Masango, Charles A
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
What has Translation Theory got to learn from Contemporary Practice? [PDF]
, 2004 There has long been a traditional animosity between practising translators and the theoreticians residing in the ‘Ivory Tower’ of the University. In the past, this was due to the judgmental attitude that theory would assume in relation to the translation
Bennett, Karen
core
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
Is Auditor Independence Influenced by Non-Audit Services? A Stakeholders’ Viewpoint [PDF]
Pakistan Journal of Commerce and Social Sciences, 2020 The auditor may provide numerous services to their clients covering audit and non-audit services (NAS). These services have been considered as a combination of services offering varying results for client firms.
Muhammad Ramzan +2 more
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