Results 141 to 150 of about 827,412 (367)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Feministische Theorien [PDF]

open access: yes, 2004
my article provides an overview on following subjects: beginnings and backgrounds of feminist theory; literary theory, literary criticism; equality and difference; women's studies and feminism of difference in France; deconstructive feminism literary ...
Babka, Anna
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Between Ideals and Reality: A Critical Discourse Analysis of Nigeria’s Fundamental Objectives and Directive Principles of State Policy

open access: yesABUAD Journal of the Humanities-AGIDIGBO
The Fundamental Objectives and Directive Principles of State Policy of nations may not be legally enforceable, they are foundational to the vision of governance in any constitutional democracy.
Taiwo Joshua AJENIFARI   +1 more
doaj   +1 more source

Becoming “Arturo Ripstein”? On collaboration and the “author function” in the transnational film adaptation of El lugar sin límites [PDF]

open access: yes, 2014
The article sets out a detailed case study of Mexican director Arturo Ripstein’s film adaptation of Chilean writer José Donoso’s 1966 short novel El lugar sin límites (‘The Place without Limits’, aka ‘Hell Has No Limits’), which featured a significant ...
Grant, Catherine
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Women and Intertextuality: On the Example of Margaret Atwood’s The Penelopiad [PDF]

open access: yes, 2014
The aim of the study is to consider feminist retellings of myths and legends. As an example, Margaret Atwood’s book The Penelopiad is analyzed. The interpretation is situated in a broader context of intertextual practices characteristic of the feminist
Lisowska, Katarzyna
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Contexts and pragmatic strategies of COVID-19 related cartoons in Nigeria

open access: yesLanguage and Semiotic Studies
The global outbreak of the coronavirus pandemic has been experienced differently by people depending on their socio-cultural contexts. These varied experiences are expressed in various forms of communication, including cartoons.
Olajimbiti Ezekiel Opeyemi   +1 more
doaj   +1 more source

Present directions of German exile studies in the USA [PDF]

open access: yes, 2012
This essay considers the present state of U.S. scholarship on German exile Literature, focusing on the recent move from a purely literary toward a social and cultural perspective. This move becomes evident in research projects on refugee children as well
Moeller, Hans-Bernhard
core  

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