Results 111 to 120 of about 668,697 (310)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Legal Classics: After Deconstructing the Legal Canon [PDF]
, 1994 The debate over the canon has gripped the University in recent years. Defenders of the canon argue that canonical texts embody timeless and universal themes, but critics argue that the process of canonization subordinates certain people and viewpoints ...
Mootz, Francis J., III
core +2 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Beauty and the Beastly Prime Minister [PDF]
, 2014 This essay examines the so-called “turn to beauty” in British fiction since the 1990s as a response to the political and social consequences of Thatcherism. Focusing primarily on four texts—Jonathan Coe’s What a Carve Up! (1994), Julian Barnes’s England,
Su, John J.
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Allegory as Experiential Communication: Metaphorical Mapping between Bunyan’s Emotions and The Pilgrim’s Progress [PDF]
, 2018 John Bunyan’s The Pilgrim’s Progress (1678) is a classic example of allegory. While literary critics tend to minimize allegory’s value as a mode, The Pilgrim’s Progress demonstrates a proclivity for genre-transcending techniques that encourage looking at
Sitterding, Philip
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Téoros, 2018 Each literary city attracts a different kind of tourism. Based on a case study of Santiago de Compostela, we will focus on the convergence of ideological, ethnographic, and literary subjects in the construction of a literary city.
Arantxa Fuentes Ríos
doaj
Формалистические аспекты литературной теории Бориса Якубського [PDF]
, 2011 In the article study of literature looks of Boris Jakubskij are analysed to formalism, in particular on such concepts, as a «literary evolution», «literary influence», «literary system».У статті проаналізовано літературознавчі погляди Бориса Якубського ...
Сінченко, Олексій Дмитрович
core