Results 41 to 50 of about 14,284 (263)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Rayah Al-IslamLiterary texts are good literary heritage, both ancient and modern, poetry and prose, as well as materials through which students' linguistic, intellectual and expressive skills are developed.
Mulyadi Mulyadi, Bakri Muhammad Bakheit
doaj +1 more source
Repères, 2012 Reading contexts and materials in French classes have been diversified especially through the introduction of ICT and Internet-based documentary research in class.
Claire-Marie Greiner-Mourez
doaj +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
History of literature and other sciences [PDF]
تاریخ ادبیات, 2013 The discussion about the history of literature, its necessity and how to compile it is one of the topics that has been the focus of researchers and literary critics especially in the last two decades, and each of them has looked at the history of ...
احمد خاتمی
doaj
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Fiction discourse through the prism of the target culture (translatological aspect) [PDF]
Актуальные проблемы филологии и педагогической лингвистикиThis article is devoted to a diachronic study of the linguacultural and pragmatic aspects of literary translation from the perspective of the original texts’ transformation in the recipient culture.
Irina D. Volkova
doaj +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
استفاده از رویکرد تعامل زیباشناسانه در خواندن متون ادبی جهت رشد مهارت خواندن در زبان دوم
Naqd-i Zabān va Adabīyyāt-i Khārijī, 2014 Different approaches may be used in teaching or developing reading comprehension skills. The present study is an attempt to see if aesthetic transaction approach in reading literary texts can lead to better achievement in this regard.
محمد فروزانی +1 more
doaj