Results 51 to 60 of about 6,521 (267)

The Influence of Chenwei on Han Dynasty Literature and Literary Theory

open access: yesJournal of Chinese Humanities, 2022
Apocryphal chenwei ideas and beliefs rose to prominence in the Han dynasty as a political and cultural movement that became closely intertwined with orthodox classical scholarship. These ideas and beliefs profoundly influenced the literature and literary
Fengyi Fengyi Zhang (張峰屹) Zhang
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Literatuurteorie, literatuurwetenskaplike metode en Christelike wetenskapsbeoefening*

open access: yesKoers : Bulletin for Christian Scholarship, 1984
In this article the author attempts to highlight the conditions which have to be com plied with if literary critics working from different theoretical paradigms wish to communicate meaningfully.
J. Swanepoel
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

The Family Saga as a Bestseller Strategy

open access: yesAkademisk Kvarter, 2013
In the post-millennial years, Danish literature has witnessed a veritable wave of biographically based, regionally rooted family sagas. One important factor of this surge is a reaction against a polarization in the Danish literature of the 1990s between,
Anker Gemzøe
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Gender and Latin American Literature

open access: yesFeminismo/s, 2003
In this paper I will analyse the concepts of women and literary canon, gender and South-american literature, gender theories and Southamerican literary theory. In order to support my analysis I will study three examples and revise this field of study.
María Caballero Wangüemert
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Des veillées d’écriture. Valeurs du texte et décentrement du lecteur : la part de l’écriture

open access: yesRepères, 2009
Our work deals with the procedures of decentring which are inherent to competent literary reading. Using analyses employing Deleuze’s theories (fonctionnement en rhizome2) as well as the theories of the reception of texts and the rhetoric of values, we ...
Daniel Claustre, Martine Jacques
doaj   +1 more source

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