Results 61 to 70 of about 6,521 (267)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A modest proposal: Linguistics and literary studies

Canadian Journal of Applied Linguistics, 2007
Linguistics should make significant contributions to literary and critical theory, but has failed to do so. This paper investigates the reasons for the failure and suggests an approach based in Relevance Theory for a working relationship between literary
Anne Furlong
doaj  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Al hilo de la literatura latinoamericana: estudios literarios/estudios culturales / To the thread of Latin American literature: literary studies / cultural studies

Kamchatka: Revista de Análisis Cultural, 2017
Resumen: El presente trabajo constituye un recorrido bibliográfico por la crítica y la teoría literaria hispanoamericana de los últimos 50 años, sin afán de exhaustividad, como tarea colectiva (congresos etc) y personal. Sus hitos más significativos son:
María Caballero Wangüemert
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Russian Literary Theories in Italy: Translations and Research (1991-2023)

Studi Slavistici
This article provides an overview of the state of translation and research on Russian literary theories published in Italy from 1991 to 2023. Particular attention is given to the wide range of perspectives and activities put forward by national literary
Giuseppina Larocca
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Pragmatismus Johna Deweyho a literární teorie Wolfganga Isera // John Dewey’s pragmatism and Wolfgang Iser’s literary theory [PDF]

Svět Literatury, 2016
The main aim of the text is to show the close relations between John Deweyʼs pragmatist theory of art and Wolfgang Iserʼs literary theory. Although there is a little theoretical attention paid to the connection of Deweyʼs and Iserʼs theories, the study
Martin Kaplický
doaj  

Literatur kritika eta teoria kritikoak: berauon historia eta arkeologia

Anuario del Seminario de Filología Vasca "Julio de Urquijo", 1990
This article deals with literary criticism's history, from its origins to its demise and the rise of the so-called "critical theories" as taking over from the former.
Joseba Gabilondo
doaj   +1 more source