Results 101 to 110 of about 13,992,363 (305)
Belajar Berfilsafat Melalui Lirik Tembang
INSANIA: Jurnal Pemikiran Alternatif Kependidikan, 2015 In this paper song lyrics are seen as a literary work. They are identical in nature to poems. However, to most of us, song lyrics are more familiar than poems.
Suwartono Suwartono
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Гуманитарные и юридические исследования, 2021 Works of the Russian historians of the first half of the XIX century had a number of signs of similarity to works of fiction. In particular, one of such signs was that the plot reminded a literary work plot.
O. N. Shevtsova
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Rushlight: The Literary Supplement [1928?]
, 1928 Wheaton College (Norton, MA) student literary magazine.The Old Barnacle ClubSong of a Thousand Valentines"The Reconciliation"The Reformation of Louise: A story with a moralAssault and BatteryAn AppealThe Keeper of The BookshopOver the WallForegin Gods ...
Adah Hatch +10 more
core
ReligionsThe missionaries’ agendas to meet South Asian had brutal effects on Christianity in the nineteenth and twentieth centuries. There are pieces that have critiqued the roles of missionaries, dismantling the agendas of Western Christianity, introducing the ...
Qiuyi Shi
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source