Results 161 to 170 of about 5,176,497 (219)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Additional Considerations in Pediatric Clavicle Fracture Non-Union: An Under-Recognized Clinical Entity. [PDF]

J Orthop Case Rep
Qureshi NA.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Observed Versus Expected Use of Diagnostic Imaging and Radiotherapy in Prostate Cancer in the Lazio Region (Italy): An Integrated Population-Based and Literature-Informed Framework for Healthcare Planning. [PDF]

Healthcare (Basel)
Ferranti M, Nardi A, Zijno M, Carloni E, Lopes S, Cozzi I, Santelli E, Farchi S, D'Ippoliti D, Michelozzi P, Pinnarelli L.   +10 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Underrepresented transition factors from social sciences in energy and emissions modeling

Kunnas S, Trutnevyte E.
europepmc   +1 more source

Non-clinical indicators of infertility and fertility care: a scoping review protocol. [PDF]

BMJ Open
Mburu G, Zhao L, Mei M, Men P, Boivin J, Kiarie J.   +5 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Lyme Disease Presenting as Rupture Baker's Cyst: Case Report and Literature Review. [PDF]

Clin Med Insights Case Rep
Ghali A, Mody-Bailey N, Jabin M, Abdou M, Hussain M, Abdelgawad A.   +5 more
europepmc   +1 more source