Results 211 to 220 of about 17,408,778 (259)

Literature And Poetry [PDF]

, 1994
Jacob, Max
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Exploring the Characteristics and Outcomes of Centenarian Patients Admitted to Intensive Care Units: A Systematised Narrative Review. [PDF]

Cureus
Reyneke C, Raykateeraroj N, Suh J, Zand J, Lee DK, Weinberg L.   +5 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Feasibility of identifying factors related to Alzheimer's disease and related dementia in real-world data. [PDF]

JAMIA Open
Huang Y, Li Q, Chen A, Li Y, Chuang YN, Hu X, Guo SJ, He X, Pang Y, Zhou J, Wu Y, Guo Y, Bian J.   +12 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Tibial tunnel malposition is a risk factor for osteoarthritis following ACL reconstruction at long term follow up: a retrospective study. [PDF]

SICOT J
Erard J, Rarchaert M, Andriollo L, Batailler C, Lustig S, Servien E.   +5 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

An Isolated Plantar Medial Navicular Dislocation Without Associated Body Fracture Following Low Energy Trauma. [PDF]

Case Rep Orthop
Mohammad S, Small R, Erbst M, Nicholas C.   +3 more
europepmc   +1 more source