Results 241 to 250 of about 17,762,432 (299)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Measuring the health benefits of genome and exome sequencing: a systematic review of economic evaluations. [PDF]

Front Public Health
Riccio M, Rosso A, Siena LM, Baccolini V, Migliara G, Sciurti A, Isonne C, Iera J, Pierri F, Marzuillo C, De Vito C, La Torre G, Villari P.   +12 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Conceptualising the experience of having TB: a global qualitative study. [PDF]

IJTLD Open
Oberdhan D, Hill M, Gillman A, McGale N, Dandy J, Abdullaev T, Dara M.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correction: Meeting abstracts from the IRC Nation Congress-Italian Resuscitation Conference 2025. [PDF]

Scand J Trauma Resusc Emerg Med
europepmc   +1 more source

Compassionate communities, Māori ageing and end-of-life: A systematic review. [PDF]

Palliat Care Soc Pract
Carey M, Mason K, Fox L, Moeke-Maxwell T, Gott M.   +4 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Primary Literature as the Course Design Centerpiece in a General Chemistry Course That Prepares Undergraduates for Research. [PDF]

ACS Omega
Knoerzer TA, Gardner KA, Reimann MD, Hicks BW.   +3 more
europepmc   +1 more source

Systematic literature review of the relationship between adolescents' screen time, sleep and mental health [PDF]

, 2020
Martin, Anne, McDaid, Lisa, McMellon, Christina, Pugmire, Juliana, Riddell, Julie, Simpson, Sharon, Skivington, Kathryn, Wells, Valerie   +7 more
core   +1 more source