Results 111 to 120 of about 521,182 (330)

The Chronotopic Imagination in Literature and Film [PDF]

open access: yes, 2010
In this contribution, I would like to examine the way in which Bakhtin, in the two essays dedicated to the chronotope, lays the foundations for a theory of literary imagination.
Keunen, Bart
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

A Poet Builds a Nation: Hafez as a Catalyst in Emerson’s Process of Developing American Literature [PDF]

open access: yes, 2014
Numerous studies have tried to elucidate the relationship between Emerson and Hafez. While most of these studies laid emphasis on influence of Hafez on Emerson and others on similarity and/or infatuation, they left untouched some vital historical aspects
Adineh Khojastehpour   +1 more
core   +3 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

The truth about fiction [PDF]

open access: yes, 1994
Ingarden distinguishes four strata making up the structure of the literary work of art: the stratum of word sounds and sound-complexes; the stratum of meaning units; the stratum of represented objectivities (characters, actions, settings, and so forth ...
Seifert, Josef, Smith, Barry
core  

Reading Books and Reading Minds: Differential Effects of Wonder and The Crossover on Empathy and Theory of Mind [PDF]

open access: yes, 2017
We tested sixth graders for empathy and theory of mind before and after an academic unit on either Wonder or The Crossover. Wonder was associated with improved perspective-taking; students who read The Crossover increased in concern for others.
Louise Freeman
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

History, Literature, and Authority in International Law [PDF]

open access: yes, 2018
One consequence of international law’s recent historical turn has been to sharpen methodological contrasts between intellectual history and international law. Scholars including Antony Anghie, Anne Orford, Rose Parfitt, and Martti Koskenniemi have taken
Christopher Warren
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Educational programme "The literary theory" [PDF]

open access: yes, 2016
Рабочая учебная программа "Теория литературы" для студентов направления "Филология. Язык и литература (английская)".Робоча навчальна програма "Теорія літератури"розроблена для студентів напряму "Філологія.
Хамедова, Ольга Анатоліївна
core  

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