Results 101 to 110 of about 112,365 (262)

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

Stochastic and deterministic processes influencing mountain mire diatom communities across spatial scales

Ecography, EarlyView.
Understanding how deterministic and stochastic processes influence the shape of microorganism community assembly across different spatial scales is essential for disentangling biodiversity patterns. Mires are nutrient‐poor and heterogeneous wetlands that form isolated habitats supporting highly diverse diatom assemblages, particularly in mountainous ...
Fernanda Gonzalez‐ Saldias, Angel Rain‐ Franco, Joan Gomà, Jorge García‐ Girón, Aaron Pérez‐ Haase   +4 more
wiley   +1 more source

Pre‐industrial land‐use limits contemporary shrub encroachment in the French Alps

Ecography, EarlyView.
Shrub encroachment has become a global phenomenon in recent decades. While global warming in the Arctic is often cited as the primary cause, human‐managed mountain regions have experienced intense historical land‐use that may also play a considerable role.
Baptiste Nicoud, Florian Carrière, Arthur Bayle, Christian Devlieger, Philippe Choler, Christophe Corona, Sandra Lavorel   +6 more
wiley   +1 more source

Indices for Hazardous Litter Items

Marine Pollution Bulletin
We consider appropriate indices for hazardous, sharp or toxic, litter items. It is demonstrated that a previously published hazardous items index for litter beach monitoring is dependent on the study area and so cannot be compared across different studies with different study areas.
Jon, Barry, Thomas, Bartos
openaire   +2 more sources

By‐product of heparin extraction as a sustainable alternative to enhance the use of nitrogen in agriculture

Environmental Progress &Sustainable Energy, EarlyView.
Abstract This study evaluates the potential of a new organic fertilizer derived from porcine intestinal mucosa (designated BHE), a by‐product of the heparin extraction process, as a sustainable nitrogen (N) source for agriculture. The work was conducted in two stages: (i) chemical and spectroscopic characterization of BHE compared with poultry litter ...
Aline Zanquetti, Felipe Augusto Bueno Rossi, Jonatas Thiago Piva, Larissa Macedo dos Santos‐Tonial   +3 more
wiley   +1 more source

Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency

Epilepsia, EarlyView.
Abstract Objective Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.
Roberto Ramos‐Mondragon, Shuyun Wang, Qinghua Liu, Chunling Chen, Alexander M. Greiner, Abigail M. Marx, Maya Shih, Jack M. Parent, Barry London, Lori L. Isom   +9 more
wiley   +1 more source

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, EarlyView.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Transfer Dynamics of Litter: Introduction to New Vectors in the Mobility of Terrestrial Litter

Next Research
Rivers are the primary contributor to marine plastics, transporting litter from inland sources through natural drainage systems. Despite an agreement among researchers that waste littered on land has the potential to enter river systems, there lacks specific quantification of the forces that facilitate transport. Although meteorological conditions (e.g.
Randa L. Kachef, Kristofer Chan, Bruce E. Main, Michael A. Chadwick   +3 more
openaire   +2 more sources